STAU1

Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene.[5][6][7]

STAU1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DKK
Identifiers
Aliases	STAU1, PPP1R150, STAU, staufen double-stranded RNA binding protein 1
External IDs	OMIM: 601716 MGI: 1338864 HomoloGene: 3384 GeneCards: STAU1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.13 Start 49,113,339 bp[1] End 49,188,367 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 166,947,549 bp[2] End 166,996,299 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein phosphatase 1 binding • GO:0001948 protein binding • double-stranded RNA binding • RNA binding Cellular component • cytoplasm • cell body • rough endoplasmic reticulum • membrane • cell membrane • microtubule associated complex • neuronal cell body • dendrite • endoplasmic reticulum • cytoplasmic ribonucleoprotein granule • neuron projection • Stress granule • extracellular exosome • cytosol • glutamatergic synapse Biological process • positive regulation of long-term synaptic potentiation • positive regulation by virus of viral protein levels in host cell • cellular response to oxidative stress • positive regulation of viral genome replication • modulation of chemical synaptic transmission • modification of postsynaptic structure • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6780	20853
Ensembl	ENSG00000124214	ENSMUSG00000039536
UniProt	O95793	Q9Z108
RefSeq (mRNA)	NM_001037328 NM_004602 NM_017452 NM_017453 NM_017454 NM_001319134 NM_001319135 NM_001322927 NM_001322928 NM_001322929 NM_001322930 NM_001322931 NM_001322932 NM_001322933	NM_001109905 NM_001109906 NM_001291160 NM_011490
RefSeq (protein)	NP_001032405 NP_001306063 NP_001306064 NP_001309856 NP_001309857 NP_001309858 NP_001309859 NP_001309860 NP_001309861 NP_001309862 NP_004593 NP_059346 NP_059347 NP_059348	NP_001103375 NP_001103376 NP_001278089 NP_035620
Location (UCSC)	Chr 20: 49.11 – 49.19 Mb	Chr 2: 166.95 – 167 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.[7]

STAU1 is associated with stress granules.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000124214 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039536 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. DesGroseillers L, Lemieux N (Feb 1997). "Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization". Genomics. 36 (3): 527–529. doi:10.1006/geno.1996.0499. PMID 8884277.
6. Kim YK, Furic L, Desgroseillers L, Maquat LE (Jan 2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326. S2CID 16786108.
7. "Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)".
8. Thomas MG, Martinez Tosar LJ, Loschi M, Pasquini JM, Correale J, Kindler S, Boccaccio GL (January 2005). "Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes". Molecular Biology of the Cell. 16 (1): 405–420. doi:10.1091/mbc.E04-06-0516. PMC 539183. PMID 15525674.

Further reading

• Kiebler MA, DesGroseillers L (2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
• Marión RM, Fortes P, Beloso A, et al. (1999). "A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum". Mol. Cell. Biol. 19 (3): 2212–2219. doi:10.1128/mcb.19.3.2212. PMC 84014. PMID 10022908.
• Wickham L, Duchaîne T, Luo M, et al. (1999). "Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum". Mol. Cell. Biol. 19 (3): 2220–2230. doi:10.1128/mcb.19.3.2220. PMC 84015. PMID 10022909.
• Falcón AM, Fortes P, Marión RM, et al. (1999). "Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro". Nucleic Acids Res. 27 (11): 2241–2247. doi:10.1093/nar/27.11.2241. PMC 148787. PMID 10325410.
• Mouland AJ, Mercier J, Luo M, et al. (2000). "The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation". J. Virol. 74 (12): 5441–5451. doi:10.1128/JVI.74.12.5441-5451.2000. PMC 112028. PMID 10823848.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–871. doi:10.1038/414865a. PMID 11780052.
• Monshausen M, Rehbein M, Richter D, Kindler S (2002). "The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1". J. Neurochem. 81 (3): 557–564. doi:10.1046/j.1471-4159.2002.00887.x. PMID 12065664. S2CID 41323424.
• Luo M, Duchaîne TF, DesGroseillers L (2002). "Molecular mapping of the determinants involved in human Staufen-ribosome association". Biochem. J. 365 (Pt 3): 817–824. doi:10.1042/BJ20020263. PMC 1222739. PMID 12133005.
• Ohashi S, Koike K, Omori A, et al. (2002). "Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor". J. Biol. Chem. 277 (40): 37804–37810. doi:10.1074/jbc.M203608200. PMID 12147688.
• Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–8837. doi:10.1523/jneurosci.22-20-08827.2002. PMID 12388589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Macchi P, Kroening S, Palacios IM, et al. (2003). "Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner". J. Neurosci. 23 (13): 5778–5788. doi:10.1523/jneurosci.23-13-05778.2003. PMID 12843282.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Chatel-Chaix L, Clément JF, Martel C, et al. (2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Mol. Cell. Biol. 24 (7): 2637–2648. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–2420. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Brendel C, Rehbein M, Kreienkamp HJ, et al. (2005). "Characterization of Staufen 1 ribonucleoprotein complexes". Biochem. J. 384 (Pt 2): 239–246. doi:10.1042/BJ20040812. PMC 1134106. PMID 15303970.