STAU2

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.[5][6]

STAU2
Identifiers
Aliases	STAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDs	OMIM: 605920 MGI: 1352508 HomoloGene: 8666 GeneCards: STAU2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.11 Start 73,420,369 bp[1] End 73,747,708 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A3 Start 16,228,674 bp[2] End 16,520,112 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • double-stranded RNA binding • GO:0001948 protein binding • RNA binding Cellular component • cytoplasm • microtubules • nucleolus • endoplasmic reticulum • membrane • cell nucleus Biological process • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27067	29819
Ensembl	ENSG00000040341	ENSMUSG00000025920
UniProt	Q9NUL3	Q8CJ67
RefSeq (mRNA)	NM_014393 NM_001164380 NM_001164381 NM_001164382 NM_001164383 NM_001164384 NM_001164385	NM_001111272 NM_025303 NM_001347044 NM_001347045
RefSeq (protein)	NP_001157852 NP_001157853 NP_001157854 NP_001157855 NP_001157856 NP_001157857 NP_055208	NP_001104742 NP_001333973 NP_001333974 NP_079579
Location (UCSC)	Chr 8: 73.42 – 73.75 Mb	Chr 1: 16.23 – 16.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000040341 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025920 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
6. "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

Further reading

• Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
• Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
• Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. PMID 12140260.