STH (gene)

Saitohin is a protein that in humans is encoded by the STH gene.[3][4][5]

STH
Identifiers
Aliases	STH, MAPTIT, saitohin
External IDs	OMIM: 607067 HomoloGene: 88448 GeneCards: STH
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,999,250 bp[1] End 45,999,694 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell nucleus • cytoplasm • perinuclear region of cytoplasm Biological process • positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	246744	n/a
Ensembl	ENSG00000256762 ENSG00000281139	n/a
UniProt	Q8IWL8	n/a
RefSeq (mRNA)	NM_001007532	n/a
RefSeq (protein)	NP_001007533	n/a
Location (UCSC)	Chr 17: 46 – 46 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. ENSG00000281139 GRCh38: Ensembl release 89: ENSG00000256762, ENSG00000281139 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Conrad C, Vianna C, Freeman M, Davies P (May 2002). "A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease". Proc Natl Acad Sci U S A. 99 (11): 7751–6. doi:10.1073/pnas.112194599. PMC 124341. PMID 12032355.
4. Gao L, Tse SW, Conrad C, Andreadis A (Nov 2005). "Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6". J Biol Chem. 280 (47): 39268–72. doi:10.1074/jbc.M506116200. PMID 16186110.
5. "Entrez Gene: STH saitohin".

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Cook L, Brayne CE, Easton D, et al. (2002). "No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease". Ann. Neurol. 52 (5): 690–1. doi:10.1002/ana.10362. PMID 12402275. S2CID 37700445.
• Verpillat P, Ricard S, Hannequin D, et al. (2002). "Is the saitohin gene involved in neurodegenerative diseases?". Ann. Neurol. 52 (6): 829–32. doi:10.1002/ana.10384. PMID 12447938. S2CID 35687241.
• Zekanowski C, Pepłońska B, Styczyńska M, et al. (2003). "Mutation screening of the MAPT and STH genes in Polish patients with clinically diagnosed frontotemporal dementia". Dementia and Geriatric Cognitive Disorders. 16 (3): 126–31. doi:10.1159/000070999. PMID 12826737. S2CID 24166927.
• Combarros O, Rodero L, Infante J, et al. (2003). "Age-dependent association between the Q7R polymorphism in the Saitohin gene and sporadic Alzheimer's disease". Dementia and Geriatric Cognitive Disorders. 16 (3): 132–5. doi:10.1159/000071000. PMID 12826738. S2CID 42452606.
• de Silva R, Hope A, Pittman A, et al. (2004). "Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy". Neurology. 61 (3): 407–9. doi:10.1212/01.wnl.0000073140.25533.90. PMID 12913211. S2CID 38636041.
• Pepłońska B, Zekanowski C, Religa D, et al. (2003). "Strong association between Saitohin gene polymorphism and tau haplotype in the Polish population". Neurosci. Lett. 348 (3): 163–6. doi:10.1016/S0304-3940(03)00788-2. PMID 12932819. S2CID 10736456.
• Johansson A, Zetterberg H, Håkansson A, et al. (2006). "TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease". Neuro-Degenerative Diseases. 2 (1): 28–35. doi:10.1159/000086428. PMID 16909000. S2CID 6644618.