STK16

Serine/threonine-protein kinase 16 is an enzyme that in humans is encoded by the STK16 gene.[5][6]

STK16
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BUJ
Identifiers
Aliases	STK16, KRCT, MPSK, PKL12, TSF1, serine/threonine kinase 16, PSK, hPSK
External IDs	OMIM: 604719 MGI: 1313271 HomoloGene: 2739 GeneCards: STK16
EC number	2.7.10.2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,245,455 bp[1] End 219,250,337 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 75,210,838 bp[2] End 75,215,606 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • non-membrane spanning protein tyrosine kinase activity • GO:0001948 protein binding • ATP binding • kinase activity • protein serine/threonine kinase activity Cellular component • Golgi-associated vesicle • perinuclear region of cytoplasm • membrane • cytoplasm • cytosol Biological process • autophosphorylation • peptidyl-tyrosine phosphorylation • protein phosphorylation • transcription from RNA polymerase II promoter • phosphorylation • positive regulation of transcription from RNA polymerase II promoter • cellular response to transforming growth factor beta stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8576	20872
Ensembl	ENSG00000115661	ENSMUSG00000026201
UniProt	O75716	O88697
RefSeq (mRNA)	NM_001008910 NM_003691 NM_032768 NM_001330213 NM_001330214 NM_001330215	NM_001277992 NM_011494
RefSeq (protein)	NP_001008910 NP_001317142 NP_001317143 NP_001317144	NP_001264921 NP_035624
Location (UCSC)	Chr 2: 219.25 – 219.25 Mb	Chr 1: 75.21 – 75.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STK16 has been shown to interact with NAGK.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000115661 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026201 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ligos JM, Gerwin N, Fernández P, Gutierrez-Ramos JC, Bernad A (August 1998). "Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases". Biochemical and Biophysical Research Communications. 249 (2): 380–4. doi:10.1006/bbrc.1998.9163. PMID 9712705.
6. "Entrez Gene: STK16 serine/threonine kinase 16".
7. Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A (February 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". The Journal of Biological Chemistry. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Berson AE, Young C, Morrison SL, Fujii GH, Sheung J, Wu B, Bolen JB, Burkhardt AL (June 1999). "Identification and characterization of a myristylated and palmitylated serine/threonine protein kinase". Biochemical and Biophysical Research Communications. 259 (3): 533–8. doi:10.1006/bbrc.1999.0811. PMID 10364453.
• Ohta S, Takeuchi M, Deguchi M, Tsuji T, Gahara Y, Nagata K (September 2000). "A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway". The Biochemical Journal. 350 Pt 2 (2): 395–404. doi:10.1042/0264-6021:3500395. PMC 1221266. PMID 10947953.
• Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, Bernad A (February 2002). "Functional interaction between the Ser/Thr kinase PKL12 and N-acetylglucosamine kinase, a prominent enzyme implicated in the salvage pathway for GlcNAc recycling". The Journal of Biological Chemistry. 277 (8): 6333–43. doi:10.1074/jbc.M105766200. PMID 11741987.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Guinea B, Ligos JM, Laín de Lera T, Martín-Caballero J, Flores J, Gonzalez de la Peña M, García-Castro J, Bernad A (January 2006). "Nucleocytoplasmic shuttling of STK16 (PKL12), a Golgi-resident serine/threonine kinase involved in VEGF expression regulation". Experimental Cell Research. 312 (2): 135–44. doi:10.1016/j.yexcr.2005.10.010. PMID 16310770.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.