STK17A

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.[3]

STK17A
Identifiers
Aliases	STK17A, DRAK1, serine/threonine kinase 17a
External IDs	OMIM: 604726 HomoloGene: 55846 GeneCards: STK17A
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 43,582,758 bp[1] End 43,650,713 bp[1]
Gene ontology Molecular function • kinase activity • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • ATP binding Cellular component • cell nucleus • cell membrane • nuclear speck Biological process • positive regulation of apoptotic process • positive regulation of fibroblast apoptotic process • protein phosphorylation • GO:0007243 intracellular signal transduction • regulation of reactive oxygen species metabolic process • phosphorylation • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9263	n/a
Ensembl	ENSG00000164543	n/a
UniProt	Q9UEE5	n/a
RefSeq (mRNA)	NM_004760	n/a
RefSeq (protein)	NP_004751	n/a
Location (UCSC)	Chr 7: 43.58 – 43.65 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.[3]

References

1. GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Serine/threonine kinase 17a".

Further reading

• Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
• Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
• Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.