SULT4A1

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.[5][6]

SULT4A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZD1
Identifiers
Aliases	SULT4A1, BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1, sulfotransferase family 4A member 1
External IDs	OMIM: 608359 MGI: 1888971 HomoloGene: 49378 GeneCards: SULT4A1
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 43,824,509 bp[1] End 43,862,513 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E2 Start 84,076,097 bp[2] End 84,105,754 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • sulfotransferase activity • GO:0001948 protein binding • aryl sulfotransferase activity • identical protein binding Cellular component • cytoplasm • cytosol Biological process • sulfur compound metabolic process • steroid metabolic process • 3'-phosphoadenosine 5'-phosphosulfate metabolic process • lipid metabolism • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25830	29859
Ensembl	ENSG00000130540	ENSMUSG00000018865
UniProt	Q9BR01	P63046
RefSeq (mRNA)	NM_014351 NM_176874	NM_013873 NM_001356515
RefSeq (protein)	NP_055166	NP_038901 NP_001343444
Location (UCSC)	Chr 22: 43.82 – 43.86 Mb	Chr 15: 84.08 – 84.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130540 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018865 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Falany CN, Xie X, Wang J, Ferrer J, Falany JL (May 2000). "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain". Biochem J. 346. Pt 3: 857–64. PMC 1220923. PMID 10698717.
6. "Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113 (1–3): 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Sakakibara Y, Suiko M, Pai TG, et al. (2002). "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization". Gene. 285 (1–2): 39–47. doi:10.1016/S0378-1119(02)00431-6. PMID 12039030.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Liyou NE, Buller KM, Tresillian MJ, et al. (2004). "Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study". J. Histochem. Cytochem. 51 (12): 1655–64. doi:10.1177/002215540305101209. PMID 14623933.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Brennan MD, Condra J (2006). "Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 (1): 69–72. doi:10.1002/ajmg.b.30222. PMID 16152568.
• Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLoS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.