SUPT4H1

Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene.[5][6]

SUPT4H1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H7H
Identifiers
Aliases	SUPT4H1, SPT4, SPT4H, SUPT4H, Supt4a, SPT4 homolog, DSIF elongation factor subunit
External IDs	OMIM: 603555 MGI: 107416 HomoloGene: 68303 GeneCards: SUPT4H1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 58,345,175 bp[1] End 58,353,093 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 C|11 52.2 cM Start 87,737,552 bp[2] End 87,743,623 bp[2]
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • GO:0001948 protein binding • protein heterodimerization activity • RNA polymerase II core binding • single-stranded RNA binding Cellular component • nucleoplasm • DSIF complex • cell nucleus Biological process • chromatin remodeling • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of transcription elongation from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of DNA-templated transcription, elongation • positive regulation of DNA-templated transcription, elongation • positive regulation of transcription from RNA polymerase II promoter • mRNA processing • regulation of transcription elongation from RNA polymerase II promoter • chromatin organization • positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6827	20922
Ensembl	ENSG00000213246	ENSMUSG00000020485
UniProt	P63272	P63271
RefSeq (mRNA)	NM_003168	NM_009296 NM_001355753
RefSeq (protein)	NP_003159	NP_033322 NP_001342682
Location (UCSC)	Chr 17: 58.35 – 58.35 Mb	Chr 11: 87.74 – 87.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000213246 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020485 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM (Sep 1996). "Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene". Genomics. 34 (3): 368–75. doi:10.1006/geno.1996.0299. PMID 8786137.
6. "Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)".

Further reading

• Hartzog GA, Basrai MA, Ricupero-Hovasse SL, et al. (1996). "Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae". Mol. Cell. Biol. 16 (6): 2848–56. doi:10.1128/MCB.16.6.2848. PMC 231277. PMID 8649394.
• Wada T, Takagi T, Yamaguchi Y, et al. (1998). "DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs". Genes Dev. 12 (3): 343–56. doi:10.1101/gad.12.3.343. PMC 316480. PMID 9450929.
• Wada T, Takagi T, Yamaguchi Y, et al. (1999). "Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro". EMBO J. 17 (24): 7395–403. doi:10.1093/emboj/17.24.7395. PMC 1171084. PMID 9857195.
• Yamaguchi Y, Wada T, Watanabe D, et al. (1999). "Structure and function of the human transcription elongation factor DSIF". J. Biol. Chem. 274 (12): 8085–92. doi:10.1074/jbc.274.12.8085. PMID 10075709.
• Yamaguchi Y, Takagi T, Wada T, et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation". Cell. 97 (1): 41–51. doi:10.1016/S0092-8674(00)80713-8. PMID 10199401. S2CID 16855257.
• Kim JB, Yamaguchi Y, Wada T, et al. (1999). "Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. PMC 84462. PMID 10454543.
• Ivanov D, Kwak YT, Guo J, Gaynor RB (2000). "Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties". Mol. Cell. Biol. 20 (9): 2970–83. doi:10.1128/MCB.20.9.2970-2983.2000. PMC 85557. PMID 10757782.
• Wada T, Orphanides G, Hasegawa J, et al. (2000). "FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH". Mol. Cell. 5 (6): 1067–72. doi:10.1016/S1097-2765(00)80272-5. PMID 10912001.
• Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation". J. Biol. Chem. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772.
• Renner DB, Yamaguchi Y, Wada T, et al. (2001). "A highly purified RNA polymerase II elongation control system". J. Biol. Chem. 276 (45): 42601–9. doi:10.1074/jbc.M104967200. PMID 11553615.
• Mo X, Dynan WS (2002). "Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites". Mol. Cell. Biol. 22 (22): 8088–99. doi:10.1128/MCB.22.22.8088-8099.2002. PMC 134733. PMID 12391174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Narita T, Yamaguchi Y, Yano K, et al. (2003). "Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex". Mol. Cell. Biol. 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062.
• Kim DK, Inukai N, Yamada T, et al. (2004). "Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex". Genes Cells. 8 (4): 371–8. doi:10.1046/j.1365-2443.2003.00638.x. PMID 12653964. S2CID 42100130.
• Kwak YT, Guo J, Prajapati S, et al. (2003). "Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties". Mol. Cell. 11 (4): 1055–66. doi:10.1016/S1097-2765(03)00101-1. PMID 12718890.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Endoh M, Zhu W, Hasegawa J, et al. (2004). "Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro". Mol. Cell. Biol. 24 (8): 3324–36. doi:10.1128/MCB.24.8.3324-3336.2004. PMC 381665. PMID 15060154.
• Mandal SS, Chu C, Wada T, et al. (2004). "Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 101 (20): 7572–7. doi:10.1073/pnas.0401493101. PMC 419647. PMID 15136722.
• Jennings BH, Shah S, Yamaguchi Y, et al. (2005). "Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila". Curr. Biol. 14 (18): 1680–4. doi:10.1016/j.cub.2004.08.066. PMID 15380072. S2CID 18780732.