SUPT6H

Transcription elongation factor SPT6 is a protein that in humans is encoded by the SUPT6H gene.[5][6]

SUPT6H
Identifiers
Aliases	SUPT6H, SPT6, SPT6H, emb-5, SPT6 homolog, histone chaperone, SPT6 homolog, histone chaperone and transcription elongation factor
External IDs	OMIM: 601333 MGI: 107726 HomoloGene: 40661 GeneCards: SUPT6H
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,662,198 bp[1] End 28,702,679 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,206,746 bp[2] End 78,245,987 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • histone binding • GO:0001948 protein binding • nucleic acid binding • nucleosome binding • RNA binding Cellular component • cell nucleus • nucleoplasm • transcription elongation factor complex • transcriptionally active chromatin Biological process • chromatin remodeling • negative regulation of histone H3-K27 methylation • mRNA transport • regulation of transcription, DNA-templated • regulation of muscle cell differentiation • regulation of mRNA export from nucleus • regulation of transcription from RNA polymerase II promoter • mRNA processing • regulation of DNA-templated transcription, elongation • transcription, DNA-templated • RNA splicing • regulation of isotype switching • GO:0022415 viral process • nucleobase-containing compound metabolic process • positive regulation of transcription elongation from RNA polymerase II promoter • chromatin silencing • transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • nucleosome organization • mRNA transcription from RNA polymerase II promoter • regulation of mRNA processing • chromatin maintenance • transport • blastocyst formation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6830	20926
Ensembl	ENSG00000109111	ENSMUSG00000002052
UniProt	Q7KZ85	Q62383
RefSeq (mRNA)	NM_003170 NM_001320755	NM_009297
RefSeq (protein)	NP_001307684 NP_003161	NP_033323
Location (UCSC)	Chr 17: 28.66 – 28.7 Mb	Chr 11: 78.21 – 78.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000109111 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002052 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics. 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID 8786132.
6. "Entrez Gene: SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Chiang PW, Stubbs L, Zhang L, Kurnit DM (1998). "Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6". Genomics. 47 (3): 426–8. doi:10.1006/geno.1997.5137. PMID 9480761.
• Wu-Baer F, Lane WS, Gaynor RB (1998). "Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation". J. Mol. Biol. 277 (2): 179–97. doi:10.1006/jmbi.1997.1601. PMID 9514752.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Endoh M, Zhu W, Hasegawa J, et al. (2004). "Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro". Mol. Cell. Biol. 24 (8): 3324–36. doi:10.1128/MCB.24.8.3324-3336.2004. PMC 381665. PMID 15060154.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.