SURF4

Surfeit locus protein 4 is a protein that in humans is encoded by the SURF4 gene.[5][6][7]

SURF4
Identifiers
Aliases	SURF4, ERV29, surfeit 4
External IDs	OMIM: 185660 MGI: 98445 HomoloGene: 6052 GeneCards: SURF4
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,361,450 bp[1] End 133,376,166 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.1 cM Start 26,920,040 bp[2] End 26,933,928 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • Golgi apparatus • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum • membrane • endoplasmic reticulum-Golgi intermediate compartment • transport vesicle • endoplasmic reticulum membrane • Golgi membrane • cell membrane • azurophil granule membrane • cytosol Biological process • early endosome to Golgi transport • positive regulation of organelle organization • protein exit from endoplasmic reticulum • Golgi organization • retrograde vesicle-mediated transport, Golgi to ER • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6836	20932
Ensembl	ENSG00000148248 ENSG00000280951	ENSMUSG00000014867
UniProt	O15260	Q64310
RefSeq (mRNA)	NM_001280788 NM_001280789 NM_001280790 NM_001280791 NM_001280792 NM_001280793 NM_033161	NM_011512
RefSeq (protein)	NP_001267717 NP_001267718 NP_001267719 NP_001267720 NP_001267721 NP_001267722 NP_149351	NP_035642
Location (UCSC)	Chr 9: 133.36 – 133.38 Mb	Chr 2: 26.92 – 26.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is located in the surfeit gene cluster, which is composed of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined.[7]

References

1. ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014867 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yon J, Jones T, Garson K, Sheer D, Fried M (Jun 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum Mol Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
6. Reeves JE, Fried M (Aug 1995). "The surf-4 gene encodes a novel 30 kDa integral membrane protein". Mol Membr Biol. 12 (2): 201–8. doi:10.3109/09687689509027508. PMID 7540914.
7. "Entrez Gene: SURF4 surfeit 4".

Further reading

• Duhig T, Ruhrberg C, Mor O, Fried M (1999). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.