SURF6

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene.[5][6]

SURF6
Identifiers
Aliases	SURF6, RRP14, surfeit 6
External IDs	OMIM: 185642 MGI: 98447 HomoloGene: 133981 GeneCards: SURF6
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,328,776 bp[1] End 133,336,188 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.08 cM Start 26,888,628 bp[2] End 26,902,879 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • RNA binding Cellular component • nucleolus • cell nucleus • nucleoplasm • granular component • cytosolic large ribosomal subunit Biological process • ribosome biogenesis • ribosomal large subunit biogenesis • ribosomal small subunit biogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6838	20935
Ensembl	ENSG00000148296 ENSG00000281309	ENSMUSG00000036160
UniProt	O75683	P70279
RefSeq (mRNA)	NM_001278942 NM_006753	NM_009298
RefSeq (protein)	NP_001265871 NP_006744	NP_033324
Location (UCSC)	Chr 9: 133.33 – 133.34 Mb	Chr 2: 26.89 – 26.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.[6]

References

1. ENSG00000281309 GRCh38: Ensembl release 89: ENSG00000148296, ENSG00000281309 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036160 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duhig T, Ruhrberg C, Mor O, Fried M (May 1999). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673.
6. "Entrez Gene: SURF6 surfeit 6".

Further reading

• Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
• Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein". DNA Cell Biol. 15 (4): 305–16. doi:10.1089/dna.1996.15.305. PMID 8639267.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro". Eur. J. Cell Biol. 75 (2): 174–83. doi:10.1016/s0171-9335(98)80059-9. PMID 9548374.
• Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus". Gene. 243 (1–2): 115–23. doi:10.1016/S0378-1119(99)00551-X. PMID 10675619.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.