SYCP1

Synaptonemal complex protein 1 is a protein that in humans is encoded by the SYCP1 gene.[5][6]

SYCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YTO
Identifiers
Aliases	SYCP1, CT8, HOM-TES-14, SCP-1, SCP1, synaptonemal complex protein 1
External IDs	OMIM: 602162 MGI: 105931 HomoloGene: 2389 GeneCards: SYCP1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 114,854,863 bp[1] End 114,995,370 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 102,818,499 bp[2] End 102,936,100 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • double-stranded DNA binding Cellular component • condensed nuclear chromosome • central element • male germ cell nucleus • chromosome • transverse filament • cell nucleus • synaptonemal complex • chromosome, centromeric region Biological process • lateral element assembly • spermatogenesis • GO:0007126 meiotic cell cycle • sperm chromatin condensation • regulation of protein localization • meiotic DNA repair synthesis • chiasma assembly • cell division • cell cycle • synaptonemal complex assembly • synapsis • reciprocal meiotic recombination • protein homotetramerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6847	20957
Ensembl	ENSG00000198765	ENSMUSG00000027855
UniProt	Q15431	Q62209
RefSeq (mRNA)	NM_001282541 NM_001282542 NM_003176	NM_011516
RefSeq (protein)	NP_001269470 NP_001269471 NP_003167 NP_001269470.1 NP_003167.2	NP_035646
Location (UCSC)	Chr 1: 114.85 – 115 Mb	Chr 3: 102.82 – 102.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000198765 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027855 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M (Jun 1998). "Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens". Proc Natl Acad Sci U S A. 95 (9): 5211–6. Bibcode:1998PNAS...95.5211T. doi:10.1073/pnas.95.9.5211. PMC 20240. PMID 9560255.
6. "Entrez Gene: SYCP1 synaptonemal complex protein 1".

Further reading

• Neumann F, Wagner C, Preuss KD, et al. (2005). "Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells". Blood. 106 (9): 3105–13. doi:10.1182/blood-2005-04-1487. PMID 16030183.
• Costa Y, Speed R, Ollinger R, et al. (2005). "Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis". J. Cell Sci. 118 (Pt 12): 2755–62. doi:10.1242/jcs.02402. PMID 15944401.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
• Kondoh N, Nishina Y, Tsuchida J, et al. (1997). "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis". Cytogenet. Cell Genet. 78 (2): 103–4. doi:10.1159/000134637. PMID 9371398.
• Meuwissen RL, Meerts I, Hoovers JM, et al. (1997). "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene" (PDF). Genomics. 39 (3): 377–84. doi:10.1006/geno.1996.4373. PMID 9119375.
• Meuwissen RL, Offenberg HH, Dietrich AJ, et al. (1993). "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes". EMBO J. 11 (13): 5091–100. doi:10.1002/j.1460-2075.1992.tb05616.x. PMC 556987. PMID 1464329.

External links

• Overview of all the structural information available in the PDB for UniProt: Q62209 (Synaptonemal complex protein 1) at the PDBe-KB.