SYTL4

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.[5]

SYTL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CSZ, 3FDW
Identifiers
Aliases	SYTL4, SLP4, synaptotagmin like 4
External IDs	OMIM: 300723 MGI: 1351606 HomoloGene: 8454 GeneCards: SYTL4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 100,674,491 bp[1] End 100,732,123 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E3 Start 133,936,385 bp[2] End 133,981,812 bp[2]
Gene ontology Molecular function • calcium ion binding • clathrin binding • metal ion binding • Rab GTPase binding • GO:0001948 protein binding • calcium-dependent phospholipid binding • syntaxin binding • phospholipid binding • neurexin family protein binding Cellular component • endosome • exocytic vesicle • membrane • transport vesicle membrane • secretory granule • nucleoplasm • cytoplasmic vesicle • presynapse • extrinsic component of membrane • microtubule organizing center • cytosol • cell membrane • platelet alpha granule membrane • synapse Biological process • negative regulation of insulin secretion • multivesicular body sorting pathway • positive regulation of protein secretion • positive regulation of exocytosis • intracellular protein transport • exocytosis • vesicle fusion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter • platelet degranulation • plasma membrane repair Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	94121	27359
Ensembl	ENSG00000102362	ENSMUSG00000031255
UniProt	Q96C24	Q9R0Q1
RefSeq (mRNA)	NM_001129896 NM_001174068 NM_080737	NM_001290717 NM_001290718 NM_001290719 NM_013757
RefSeq (protein)	NP_001123368 NP_001167539 NP_542775 NP_001357089 NP_001357090 NP_001357091 NP_001357092 NP_001357093 NP_001357094 NP_001357095 NP_001357096 NP_001357097 NP_001357098	NP_001277646 NP_001277647 NP_001277648 NP_038785
Location (UCSC)	Chr X: 100.67 – 100.73 Mb	Chr X: 133.94 – 133.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000102362 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031255 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SYTL4 synaptotagmin-like 4 (granuphilin-a)".

Further reading

• Wang J, Takeuchi T, Yokota H, Izumi T (1999). "Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells". J. Biol. Chem. 274 (40): 28542–8. doi:10.1074/jbc.274.40.28542. PMID 10497219.
• Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
• Yi Z, Yokota H, Torii S, et al. (2002). "The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules". Mol. Cell. Biol. 22 (6): 1858–67. doi:10.1128/MCB.22.6.1858-1867.2002. PMC 135591. PMID 11865063.
• Zhao S, Torii S, Yokota-Hashimoto H, et al. (2002). "Involvement of Rab27b in the regulated secretion of pituitary hormones". Endocrinology. 143 (5): 1817–24. doi:10.1210/en.143.5.1817. PMID 11956164.
• Torii S, Zhao S, Yi Z, et al. (2002). "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a". Mol. Cell. Biol. 22 (15): 5518–26. doi:10.1128/MCB.22.15.5518-5526.2002. PMC 133943. PMID 12101244.
• Fukuda M, Kanno E, Saegusa C, et al. (2002). "Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells". J. Biol. Chem. 277 (42): 39673–8. doi:10.1074/jbc.M205349200. PMID 12176990.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ciufo LF, Barclay JW, Burgoyne RD, Morgan A (2005). "Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions". Mol. Biol. Cell. 16 (2): 470–82. doi:10.1091/mbc.E04-08-0685. PMC 545880. PMID 15563604.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Plaisance V, Abderrahmani A, Perret-Menoud V, et al. (2006). "MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells". J. Biol. Chem. 281 (37): 26932–42. doi:10.1074/jbc.M601225200. PMID 16831872.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.