Sanjiv Sam Gambhir

Sanjiv Sam Gambhir (November 23, 1962 – July 18, 2020) was an American physician-scientist. He was the Virginia and D.K. Ludwig Professor in Cancer Research,[1] Chairman of the Department of Radiology[2] at Stanford University School of Medicine, and a professor by courtesy in the departments of Bioengineering and Materials Science and Engineering at Stanford University. Additionally, he served as the Director of the Molecular Imaging Program at Stanford (MIPS),[3] Canary Center at Stanford for Cancer Early Detection[4] and the Precision Health and Integrated Diagnostics Center (PHIND).[5] He authored 680 publications and had over 40 patents pending or granted.[6] His work was featured on the cover of over 25 journals including the Nature Series, Science, and Science Translational Medicine. He was on the editorial board of several journals including Nano Letters, Nature Clinical Practice Oncology, and Science Translational Medicine. He was founder/co-founder of several biotechnology companies and also served on the scientific advisory board of multiple companies. He mentored over 150 post-doctoral fellows and graduate students from over a dozen disciplines. He was known for his work in molecular imaging of living subjects and early cancer detection.

Sanjiv Sam Gambhir
Born(1962-11-23)November 23, 1962
Ambala, Haryana, India
DiedJuly 18, 2020(2020-07-18) (aged 57)
NationalityAmerican
Alma materArizona State University (B.S.), University of California, Los Angeles (M.D. & Ph.D.)
Known forMolecular Imaging, Nuclear Medicine, PET-CT, and Early Cancer Detection
AwardsInstitute of Medicine (IOM) of the US National Academies (2008)

American Association for the Advancement of Science (2014)

National Academy of Inventors (2015)
Scientific career
FieldsNuclear Medicine, Radiology, and Bioengineering
InstitutionsStanford University
Academic advisorsM.E. Phelps, S.C. Huang, and H.R. Herschman

Personal

Gambhir was born in Ambala, India and moved to the US with his parents and sister in 1969. He was raised in Phoenix, Arizona. He was married to Aruna Bodapati Gambhir and lived in the Bay Area. He died July 18, 2020 of cancer of unknown primary. His son, Milan Gambhir, was born in 1998 and died from a glioblastoma[7] in 2015.

Education and employment

Gambhir was a Phi Beta Kappa graduate of Arizona State University where he received his BS in Physics. He then entered the combined M.D-Ph.D. Medical Scientist Training Program (MSTP) at the University of California Los Angeles (UCLA) and received his MD, and his PhD in biomathematics.[8]

His first academic appointment was in 1994, at UCLA, as an Assistant Professor of Molecular & Medical Pharmacology. He was a Clinical Attending in the Nuclear Medicine Department at the Center for Health Sciences at UCLA starting in 1997. He was appointed tenure Professorship at UCLA in 2003.[9] In 2003, he moved to Stanford University and was appointed Professor of Radiology, Head of Nuclear Medicine, Director of the Molecular Imaging Program at Stanford (MIPS), Director of the Precision Health and Integrated Diagnostics (PHIND) Center,[10] Division Chief of the Canary Center for Cancer Early Detection, and Member of the Bio-X Program. He became the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research, which is an Endowed Professorship in 2009. He was appointed the Chair of Radiology in August 2011.[8][11]

Honors and awards

Gambhir received the following:

  • Taplin Award[12]
  • Holst Medal[13]
  • Academy of Molecular Imaging (AMI) Distinguished Basic Scientist of the Year Award[14]
  • Society for Molecular Imaging (SMI) Achievement Award[15]
  • Distinguished Clinical Scientist Award from the Doris Duke Charitable Foundation[16]
  • Hounsfield Medal (Imperial College London)[17]
  • Fellowship of the American Institute for Medical and Biological Engineering (AIMBE)[18]
  • Paul C. Aebersold Award[19]
  • Organizer and Co-Chair for the Nobel Symposium in Imaging (2008)
  • Inducted as a member of the American Society for Clinical Investigation (ASCI)[20]
  • Tesla Medal
  • Elected to the Institute of Medicine (IOM) of the US National Academies[21]
  • Parmley Prize
  • Radiological Society of North America (RSNA)
  • Outstanding Researcher Award[22]
  • Gopal Subramanian Lifetime Achievement Award[23]
  • George Charles de Hevesy Nuclear Pioneer Award[24]
  • Aunt Minnie Award[25]
  • Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine[26]
  • Society of Asian American Scientists in Cancer Research Award[27]
  • American Association of Indian Scientists in Cancer Research Lifetime Achievement Award[28]
  • American Association for the Advancement of Science (AAAS) Fellow Award[29]
  • J. Allyn Taylor International Prize in Medicine[30]
  • National Academy of Inventors[31]
  • American Association for the Advancement of Science[32]
  • Basic Science Teaching Award
  • Benedict Cassen Prize for Research in Molecular Imaging[33]
  • Institute of Electrical and Electronics Engineers (IEEE) Marie Sklodowska-Curie Award - IEEE Advancing Technology for Humanity[34]

Research focus

His research focused on the development of imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on the detection and management of cancer. A particular interest of his research and lab was early cancer detection including combining in vivo and in vitro diagnostics.

Major contributions

PET reporter gene technology, multimodality reporter genes, imaging of gene/cell therapies, imaging of the immune system, imaging of intracellular events in living subjects (e.g., protein-protein interactions), bioluminescence resonance energy transfer (BRET) in living subjects, nanoparticle based imaging, Raman imaging in vivo and photoacoustic molecular imaging with novel imaging agents in living subjects. Decision Management Models for the use of FDG PET in cancer.

Selected publications

References
  1. "Endowed professorships for Gambhir and Relman". Stanford Report. June 2009. Retrieved 2 January 2013.
  2. "People".
  3. "Leadership".
  4. "Leadership".
  5. "Leadership".
  6. "Sanjiv Sam Gambhir, MD, PhD's Profile | Stanford Profiles". profiles.stanford.edu.
  7. "And yet, you try". Stanford Medicine. Retrieved 2016-12-10.
  8. "Sanjiv Sam Gambhir, MD, PhD's Profile | Stanford Profiles". profiles.stanford.edu.
  9. https://ektron.rsna.org/Sanjiv_Sam_Gambhir_MD_PhD.aspx
  10. "Precision Health and Integrated Diagnostics". Precision Health and Integrated Diagnostics Center at Stanford.
  11. "Sanjiv Sam Gambhir, MD, PhD, Receives 2018 Benedict Cassen Prize for Research in Molecular Imaging - SNMMI". www.snmmi.org.
  12. "May 9, 2011 - The Dean's Newsletter - Stanford University School of Medicine".
  13. "Medical Center People". news.stanford.edu.
  14. "2004 News". Molecular Imaging Program at Stanford.
  15. Gambhir Receives SMI’s Achievement Award
  16. Stanford, © Stanford University; Notice, California 94305 Copyright Complaints Trademark (November 3, 2004). "Doctors win $1.5 million awards for cancer research". Stanford University.
  17. Stanford, © Stanford University; Notice, California 94305 Copyright Complaints Trademark (March 8, 2006). "Medical Center People". Stanford University.
  18. "College of Fellows : AIMBE". Archived from the original on October 20, 2013.
  19. "Aebersold Award Presented to Gambhir". Journal of Nuclear Medicine. 47 (7): 26N. July 1, 2006. PMID 16871693 – via jnm.snmjournals.org.
  20. "The American Society for Clinical Investigation".
  21. Sanjiv Gambhir - Institute of Medicine Archived 2013-02-17 at Archive.today
  22. 2009 RSNA Outstanding Researcher
  23. The Gopal Subramanian Lifetime Achievement Award
  24. "SNM's 2011 Georg Charles de Hevesy Nuclear Pioneer Award" (PDF).
  25. "AuntMinnie.com announces winners of 2014 Minnies awards for excellence in radiology". AuntMinnie.com.
  26. "Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine". Archived from the original on May 17, 2014.
  27. "Society of Asian American Scientists in Cancer Research Award". Archived from the original on April 9, 2014.
  28. "American Association of Indian Scientists in Cancer Research Lifetime Achievement Award". Archived from the original on March 10, 2014.
  29. "American Association for the Advancement of Science (AAAS) Fellow Award".
  30. "2015 Taylor Prize Recipient | Robarts Research". www.robarts.ca.
  31. "National Academy of Inventors". www.academyofinventors.org. Retrieved 2017-01-05.
  32. "AAAS - The World's Largest General Scientific Society |". www.aaas.org. Retrieved 2017-01-10.
  33. "Benedict Cassen Prize for Research in Molecular Imaging". June 25, 2018.
  34. "Institute of Electrical and Electronics Engineers (IEEE) Marie Sklodowska-Curie Award - IEEE Advancing Technology for Humanity" (PDF).
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