Selenophosphate synthetase 1

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.[5][6]

SEPHS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FD5, 3FD6
Identifiers
Aliases	SEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	OMIM: 600902 MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 13,317,428 bp[1] End 13,348,298 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 4,881,564 bp[2] End 4,910,557 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • selenide, water dikinase activity • GTP binding • GO:0001948 protein binding • ATP binding • protein homodimerization activity • identical protein binding • protein heterodimerization activity • kinase activity Cellular component • cytoplasm • cell membrane • not the membrane • membrane • cell nucleus Biological process • cellular protein modification process • phosphorylation • selenocysteine biosynthetic process • selenium compound metabolic process • tRNA seleno-modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22929	109079
Ensembl	ENSG00000086475	ENSMUSG00000026662
UniProt	P49903 Q5T5U7	Q8BH69
RefSeq (mRNA)	NM_001195602 NM_001195604 NM_012247 NM_001375769 NM_001375770	NM_175400
RefSeq (protein)	NP_001182531 NP_001182533 NP_036379 NP_001362698	NP_780609 NP_001349636 NP_001349637 NP_001349638 NP_001349639
Location (UCSC)	Chr 10: 13.32 – 13.35 Mb	Chr 2: 4.88 – 4.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000086475 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026662 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.
6. "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tamura T, Yamamoto S, Takahata M, et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. doi:10.1073/pnas.0406313101. PMC 528966. PMID 15534230.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Saiki R, Nagata A, Kainou T, et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans". FEBS J. 272 (21): 5606–22. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699. S2CID 13735213.
• Chung HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID 16786570. S2CID 24313890.