Small nucleolar RNA snoR9
snoR9 is a non-coding RNA (ncRNA) which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.
| Small nucleolar RNA snoR9 | |
|---|---|
 Predicted secondary structure and sequence conservation of snoR9 | |
| Identifiers | |
| Symbol | snoR9 |
| Rfam | RF00065 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box |
| Domain(s) | Archaea |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
R9 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]
This snoRNA was identified in a computational search for GC-rich regions in the AT-rich genomes of hyperthermophiles.[2] This snoRNA is not related to the plant snoRNA snoR9.
References
- Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
- Klein RJ, Misulovin Z, Eddy SR (2002). "Noncoding RNA genes identified in AT-rich hyperthermophiles". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7542–7. doi:10.1073/pnas.112063799. PMC 124278. PMID 12032319.
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