Spondin 1

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.[5] It is secreted by cells of the floor plate and may be involved in axon guidance[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

SPON1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989 MGI: 2385287 HomoloGene: 4453 GeneCards: SPON1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.2 Start 13,962,723 bp[1] End 14,268,133 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 113,765,998 bp[2] End 114,043,370 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • extracellular matrix structural constituent • LBD domain binding Cellular component • extracellular matrix • extracellular region • endoplasmic reticulum lumen • extracellular • collagen-containing extracellular matrix Biological process • cell adhesion • protein O-linked fucosylation • positive regulation of protein processing • positive regulation of protein binding • negative regulation of amyloid-beta formation • positive regulation of amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10418	233744
Ensembl	ENSG00000262655	ENSMUSG00000038156
UniProt	Q9HCB6	Q8VCC9
RefSeq (mRNA)	NM_006108	NM_145584
RefSeq (protein)	NP_006099	NP_663559
Location (UCSC)	Chr 11: 13.96 – 14.27 Mb	Chr 7: 113.77 – 114.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000262655 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038156 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
6. "Entrez Gene: SPON1 spondin 1, extracellular matrix protein".

Further reading

• Nakajima D, Okazaki N, Yamakawa H (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Klar A, Baldassare M, Jessell TM (1992). "F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension". Cell. 69 (1): 95–110. doi:10.1016/0092-8674(92)90121-R. PMID 1555244. S2CID 14880785.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Miyamoto K, Morishita Y, Yamazaki M (2001). "Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary". Arch. Biochem. Biophys. 390 (1): 93–100. doi:10.1006/abbi.2001.2367. PMID 11368520.
• Gonzalez de Peredo A, Klein D, Macek B (2002). "C-mannosylation and o-fucosylation of thrombospondin type 1 repeats". Mol. Cell. Proteomics. 1 (1): 11–8. doi:10.1074/mcp.M100011-MCP200. PMID 12096136.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ho A, Südhof TC (2004). "Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2548–53. doi:10.1073/pnas.0308655100. PMC 356987. PMID 14983046.
• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pyle-Chenault RA, Stolk JA, Molesh DA (2005). "VSGP/F-spondin: a new ovarian cancer marker". Tumour Biol. 26 (5): 245–57. doi:10.1159/000087379. PMID 16103746. S2CID 13409234.
• Otsuki T, Ota T, Nishikawa T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kitagawa M, Kudo Y, Iizuka S (2006). "Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells" (PDF). Biochem. Biophys. Res. Commun. 349 (3): 1050–6. doi:10.1016/j.bbrc.2006.08.142. PMID 16965763.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9HCB6 (Spondin-1) at the PDBe-KB.