Stomatin

Stomatin also known as human erythrocyte integral membrane protein band 7 is a protein that in humans is encoded by the STOM gene.[5][6]

STOM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4FVF, 4FVG, 4FVJ
Identifiers
Aliases	STOM, BND7, EPB7, EPB72, stomatin
External IDs	OMIM: 133090 MGI: 95403 HomoloGene: 81681 GeneCards: STOM
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2 Start 121,338,987 bp[1] End 121,370,304 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 B|2 23.53 cM Start 35,313,986 bp[2] End 35,336,976 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • GO:0001948 protein binding • RNA polymerase binding • identical protein binding Cellular component • vesicle • blood microparticle • membrane • melanosome • integral component of plasma membrane • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • membrane raft • extracellular exosome • cytoskeleton • cytoplasmic vesicle • extracellular • cytoplasm • cytosol • cell membrane • azurophil granule membrane • specific granule membrane • tertiary granule membrane • integral component of membrane Biological process • regulation of ion transmembrane transport • positive regulation by host of viral genome replication • regulation of acid-sensing ion channel activity • protein homooligomerization • positive regulation of viral process • positive regulation of protein targeting to membrane • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2040	13830
Ensembl	ENSG00000148175	ENSMUSG00000026880
UniProt	P27105	P54116
RefSeq (mRNA)	NM_001270526 NM_001270527 NM_004099 NM_198194	NM_013515
RefSeq (protein)	NP_001257455 NP_001257456 NP_004090 NP_937837 NP_004090.4	NP_038543
Location (UCSC)	Chr 9: 121.34 – 121.37 Mb	Chr 2: 35.31 – 35.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

Stomatin is a 31 kDa integral membrane protein, named after the rare human haemolytic anaemia hereditary stomatocytosis. This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia.[6]

Function

This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia.[6]

Although the wide distribution of stomatin and its constitutive expression suggest an important role for this protein in cell biology, perhaps as a “house-keeping” component, its function remains undetermined. The massive presence of stomatin in membrane-protruding folds and extensions suggests a possible structural role for this protein in the formation of these structures and/or the anchorage to the actin cytoskeleton.

References

1. GRCh38: Ensembl release 89: ENSG00000148175 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026880 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hiebl-Dirschmied CM, Entler B, Glotzmann C, Maurer-Fogy I, Stratowa C, Prohaska R (Oct 1991). "Cloning and nucleotide sequence of cDNA encoding human erythrocyte band 7 integral membrane protein". Biochim Biophys Acta. 1090 (1): 123–4. doi:10.1016/0167-4781(91)90047-P. PMID 1883838.
6. "Entrez Gene: STOM stomatin".

Further reading

• Stewart GW (1997). "Stomatin". Int. J. Biochem. Cell Biol. 29 (2): 271–4. doi:10.1016/S1357-2725(96)00072-6. PMID 9147127.
• Stewart GW, Hepworth-Jones BE, Keen JN, et al. (1992). "Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes". Blood. 79 (6): 1593–601. doi:10.1182/blood.V79.6.1593.1593. PMID 1547348.
• Gallagher PG, Forget BG (1995). "Structure, organization, and expression of the human band 7.2b gene, a candidate gene for hereditary hydrocytosis". J. Biol. Chem. 270 (44): 26358–63. doi:10.1074/jbc.270.44.26358. PMID 7592848.
• Salzer U, Ahorn H, Prohaska R (1993). "Identification of the phosphorylation site on human erythrocyte band 7 integral membrane protein: implications for a monotopic protein structure". Biochim. Biophys. Acta. 1151 (2): 149–52. doi:10.1016/0005-2736(93)90098-K. PMID 8373790.
• Westberg JA, Entler B, Prohaska R, Schröder JP (1993). "The gene coding for erythrocyte protein band 7.2b (EPB72) is located in band q34.1 of human chromosome 9". Cytogenet. Cell Genet. 63 (4): 241–3. doi:10.1159/000133542. PMID 8500356.
• Unfried I, Entler B, Prohaska R (1997). "The organization of the gene (EPB72) encoding the human erythrocyte band 7 integral membrane protein (protein 7.2b)". Genomics. 30 (3): 521–8. doi:10.1006/geno.1995.1273. PMID 8825639.
• Snyers L, Thinès-Sempoux D, Prohaska R (1997). "Colocalization of stomatin (band 7.2b) and actin microfilaments in UAC epithelial cells". Eur. J. Cell Biol. 73 (3): 281–5. PMID 9243190.
• Mayer H, Salzer U, Breuss J, et al. (1998). "Isolation, molecular characterization, and tissue-specific expression of a novel putative G protein-coupled receptor". Biochim. Biophys. Acta. 1395 (3): 301–8. doi:10.1016/s0167-4781(97)00178-4. PMID 9512664.
• Snyers L, Umlauf E, Prohaska R (1998). "Oligomeric nature of the integral membrane protein stomatin". J. Biol. Chem. 273 (27): 17221–6. doi:10.1074/jbc.273.27.17221. PMID 9642292.
• Snyers L, Umlauf E, Prohaska R (1999). "Cysteine 29 is the major palmitoylation site on stomatin". FEBS Lett. 449 (2–3): 101–4. doi:10.1016/S0014-5793(99)00417-2. PMID 10338112. S2CID 19587098.
• Zhang JZ, Hayashi H, Ebina Y, et al. (1999). "Association of stomatin (band 7.2b) with Glut1 glucose transporter". Arch. Biochem. Biophys. 372 (1): 173–8. doi:10.1006/abbi.1999.1489. PMID 10562431.
• Mairhofer M, Steiner M, Mosgoeller W, et al. (2002). "Stomatin is a major lipid-raft component of platelet alpha granules". Blood. 100 (3): 897–904. doi:10.1182/blood.V100.3.897. PMID 12130500.
• Feuk-Lagerstedt E, Samuelsson M, Mosgoeller W, et al. (2002). "The presence of stomatin in detergent-insoluble domains of neutrophil granule membranes". J. Leukoc. Biol. 72 (5): 970–7. PMID 12429719.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
• Fricke B, Argent AC, Chetty MC, et al. (2003). "The "stomatin" gene and protein in overhydrated hereditary stomatocytosis". Blood. 102 (6): 2268–77. doi:10.1182/blood-2002-06-1705. PMID 12750157.
• Green JB, Fricke B, Chetty MC, et al. (2005). "Eukaryotic and prokaryotic stomatins: the proteolytic link". Blood Cells Mol. Dis. 32 (3): 411–22. doi:10.1016/j.bcmd.2004.01.016. PMID 15121101.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.

External links

• Overview of all the structural information available in the PDB for UniProt: P54116 (Mouse Erythrocyte band 7 integral membrane protein) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.