TACSTD2

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),[5] is a protein that in humans is encoded by the TACSTD2 gene.[6][7][8]

TACSTD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MAE, 2MVK, 2MVL
Identifiers
Aliases	TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, tumor-associated calcium signal transducer 2, tumor associated calcium signal transducer 2
External IDs	OMIM: 137290 MGI: 1861606 HomoloGene: 1763 GeneCards: TACSTD2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.1 Start 58,575,433 bp[1] End 58,577,252 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C1 Start 67,534,062 bp[2] End 67,535,796 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • signaling receptor activity • cadherin binding involved in cell-cell adhesion Cellular component • integral component of membrane • cytosol • lateral plasma membrane • membrane • cell membrane • integral component of plasma membrane • basal plasma membrane • extracellular exosome • cell nucleus • extracellular • bicellular tight junction Biological process • ureteric bud morphogenesis • response to stimulus • negative regulation of ruffle assembly • negative regulation of cell motility • cell surface receptor signaling pathway • negative regulation of branching involved in ureteric bud morphogenesis • cellular proliferation • regulation of epithelial cell proliferation • negative regulation of stress fiber assembly • negative regulation of substrate adhesion-dependent cell spreading • negative regulation of epithelial cell migration • visual perception • cell-cell adhesion • positive regulation of stem cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4070	56753
Ensembl	ENSG00000184292	ENSMUSG00000051397
UniProt	P09758	Q8BGV3
RefSeq (mRNA)	NM_002353	NM_020047
RefSeq (protein)	NP_002344	NP_064431
Location (UCSC)	Chr 1: 58.58 – 58.58 Mb	Chr 6: 67.53 – 67.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.[8]

This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.

References

1. GRCh38: Ensembl release 89: ENSG00000184292 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051397 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy
6. Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol. 13 (3): 1507–15. doi:10.1128/MCB.13.3.1507. PMC 359462. PMID 8382772.
7. Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet. 92 (1–2): 164–5. doi:10.1159/000056891. PMID 11306819. S2CID 9708614.
8. "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".

Further reading

• Linnenbach AJ, Wojcierowski J, Wu SA, et al. (1989). "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 27–31. Bibcode:1989PNAS...86...27L. doi:10.1073/pnas.86.1.27. PMC 286396. PMID 2911574.
• Fornaro M, Dell'Arciprete R, Stella M, et al. (1995). "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas". Int. J. Cancer. 62 (5): 610–8. doi:10.1002/ijc.2910620520. PMID 7665234. S2CID 23260113.
• El Sewedy T, Fornaro M, Alberti S (1998). "Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2". Int. J. Cancer. 75 (2): 324–30. doi:10.1002/(SICI)1097-0215(19980119)75:2<324::AID-IJC24>3.0.CO;2-B. PMID 9462726.
• Ripani E, Sacchetti A, Corda D, Alberti S (1998). "Human Trop-2 is a tumor-associated calcium signal transducer". Int. J. Cancer. 76 (5): 671–6. doi:10.1002/(SICI)1097-0215(19980529)76:5<671::AID-IJC10>3.0.CO;2-7. PMID 9610724.
• Tsujikawa M, Kurahashi H, Tanaka T, et al. (1999). "Identification of the gene responsible for gelatinous drop-like corneal dystrophy". Nat. Genet. 21 (4): 420–3. doi:10.1038/7759. PMID 10192395. S2CID 2275476.
• Nakamura T, Nishida K, Dota A, et al. (2000). "Gelatino-lattice corneal dystrophy: clinical features and mutational analysis". Am. J. Ophthalmol. 129 (5): 665–6. doi:10.1016/S0002-9394(00)00369-X. PMID 10844062.
• Kinoshita S, Nishida K, Dota A, Abbie F, et al. (2000). "Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy". Cornea. 19 (4): 551–5. doi:10.1097/00003226-200007000-00029. PMID 10928776. S2CID 43011710.
• Tsujikawa M, Tsujikawa K, Maeda N, et al. (2000). "Rapid detection of M1S1 mutations by the protein truncation test". Invest. Ophthalmol. Vis. Sci. 41 (9): 2466–8. PMID 10937555.
• Ha NT, Fujiki K, Hotta Y, et al. (2000). "Q118X mutation of M1S1 gene caused gelatinous drop-like corneal dystrophy: the P501T of BIGH3 gene found in a family with gelatinous drop-like corneal dystrophy". Am. J. Ophthalmol. 130 (1): 119–20. doi:10.1016/S0002-9394(00)00596-1. PMID 11004271.
• Tasa G, Kals J, Muru K, et al. (2001). "A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy". Invest. Ophthalmol. Vis. Sci. 42 (12): 2762–4. PMID 11687514.
• Yoshida S, Kumano Y, Yoshida A, et al. (2002). "Two brothers with gelatinous drop-like dystrophy at different stages of the disease: role of mutational analysis". Am. J. Ophthalmol. 133 (6): 830–2. doi:10.1016/S0002-9394(02)01407-1. PMID 12036680.
• Ren Z, Lin PY, Klintworth GK, et al. (2002). "Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy". Hum. Genet. 110 (6): 568–77. doi:10.1007/s00439-002-0729-z. PMID 12107443. S2CID 24052349.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ha NT, Chau HM, Cung le X, et al. (2003). "A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy". Am. J. Ophthalmol. 135 (3): 390–3. doi:10.1016/S0002-9394(02)01952-9. PMID 12614764.
• Gires O, Eskofier S, Lang S, et al. (2003). "Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter". Anticancer Res. 23 (4): 3255–61. PMID 12926061.
• Tian X, Fujiki K, Li Q, et al. (2004). "Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy". Am. J. Ophthalmol. 137 (3): 567–9. doi:10.1016/j.ajo.2003.08.008. PMID 15013888.
• Murakami A, Kimura S, Fujiki K, et al. (2004). "Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy". Jpn. J. Ophthalmol. 48 (4): 317–20. doi:10.1007/s10384-003-0064-5. PMID 15295654. S2CID 28358081.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.