TAF1B

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.[5][6]

TAF1B
Identifiers
Aliases	TAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDs	OMIM: 604904 MGI: 109577 HomoloGene: 31331 GeneCards: TAF1B
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 9,843,443 bp[1] End 9,934,416 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.3 Start 24,498,359 bp[2] End 24,558,539 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001948 protein binding • TBP-class protein binding • GO:0001187 RNA polymerase I core promoter sequence-specific DNA binding Cellular component • nucleoplasm • RNA polymerase transcription factor SL1 complex • nucleolus • cell nucleus • RNA polymerase I core factor complex Biological process • termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase I promoter • transcription, DNA-templated • transcription from RNA polymerase I promoter • RNA polymerase I transcriptional preinitiation complex assembly • transcription of nuclear large rRNA transcript from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9014	21340
Ensembl	ENSG00000115750	ENSMUSG00000059669
UniProt	Q53T94	P97358
RefSeq (mRNA)	NM_005680 NM_001318976 NM_001318977	NM_020614
RefSeq (protein)	NP_001305905 NP_001305906 NP_005671	NP_065639
Location (UCSC)	Chr 2: 9.84 – 9.93 Mb	Chr 12: 24.5 – 24.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.[6]

Interactions

TAF1B has been shown to interact with RRN3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000115750 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059669 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
6. "Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa".
7. Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (March 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.

Further reading

• Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955. S2CID 27014629.
• Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.
• Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
• Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H (2002). "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability". Oncogene. 21 (33): 5081–7. doi:10.1038/sj.onc.1205703. PMID 12140758.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054. S2CID 8913931.
• You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H (2007). "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors". PLOS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMC 1854916. PMID 17456004.