TAF3

Transcription initiation factor TFIID subunit 3 is a protein that in humans is encoded by the TAF3 gene.[5][6][7]

TAF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5C13
Identifiers
Aliases	TAF3, TAF140, TAFII-140, TAFII140, TATA-box binding protein associated factor 3
External IDs	OMIM: 606576 MGI: 2388097 HomoloGene: 35415 GeneCards: TAF3
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p14 Start 7,818,505 bp[1] End 8,016,631 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A1 Start 9,914,552 bp[2] End 10,048,596 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • p53 binding • GO:0001948 protein binding • metal ion binding • protein heterodimerization activity Cellular component • cell nucleus • nucleoplasm • not the membrane • transcription factor TFIID complex Biological process • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of sequence-specific DNA binding transcription factor activity • maintenance of protein location in nucleus • transcription, DNA-templated • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83860	209361
Ensembl	ENSG00000165632	ENSMUSG00000025782
UniProt	Q5VWG9	Q5HZG4
RefSeq (mRNA)	NM_031923	NM_027748
RefSeq (protein)	NP_114129	NP_082024
Location (UCSC)	Chr 10: 7.82 – 8.02 Mb	Chr 2: 9.91 – 10.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000165632 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025782 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gangloff YG, Pointud JC, Thuault S, Carre L, Romier C, Muratoglu S, Brand M, Tora L, Couderc JL, Davidson I (Jul 2001). "The TFIID Components Human TAFII140 and Drosophila BIP2 (TAFII155) Are Novel Metazoan Homologues of Yeast TAFII47 Containing a Histone Fold and a PHD Finger". Mol Cell Biol. 21 (15): 5109–21. doi:10.1128/MCB.21.15.5109-5121.2001. PMC 87236. PMID 11438666.
6. Bereczki O, Ujfaludi Z, Pardi N, Nagy Z, Tora L, Boros IM, Balint E (Jun 2008). "TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function". BMC Mol Biol. 9: 57. doi:10.1186/1471-2199-9-57. PMC 2441632. PMID 18549481.
7. "Entrez Gene: TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Soutoglou E, Demény MA, Scheer E, et al. (2005). "The Nuclear Import of TAF10 Is Regulated by One of Its Three Histone Fold Domain-Containing Interaction Partners". Mol. Cell. Biol. 25 (10): 4092–104. doi:10.1128/MCB.25.10.4092-4104.2005. PMC 1087738. PMID 15870280.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.