TAF4B

Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene.[4][5][6]

TAF4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H3O, 2P6V
Identifiers
Aliases	TAF4B, SPGF13, TAF2C2, TAFII105, TATA-box binding protein associated factor 4b
External IDs	OMIM: 601689 MGI: 2152345 HomoloGene: 28266 GeneCards: TAF4B
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 26,225,936 bp[1] End 26,391,685 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • NF-kappaB binding • protein heterodimerization activity • GO:0001105 transcription coactivator activity • transcription factor binding • GO:0000983 RNA polymerase II general transcription initiation factor activity Cellular component • cytoplasm • cell nucleus • nucleoplasm • fibrillar center • transcription factor TFIID complex Biological process • DNA-templated transcription, initiation • cell differentiation • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • spermatogenesis • transcription, DNA-templated • oogenesis • regulation of signal transduction by p53 class mediator • positive regulation of transcription from RNA polymerase II promoter • RNA polymerase II transcriptional preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6875	72504
Ensembl	ENSG00000141384	ENSMUSG00000054321
UniProt	Q92750	G5E8Z2
RefSeq (mRNA)	NM_001293725 NM_005640	NM_001100449 NM_001369357 NM_001369358
RefSeq (protein)	NP_001280654 NP_005631	NP_001093919 NP_001356286 NP_001356287
Location (UCSC)	Chr 18: 26.23 – 26.39 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM][6]

Interactions

TAF4B has been shown to interact with RELA.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141384 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130". Cell. 87 (1): 137–46. doi:10.1016/S0092-8674(00)81330-6. PMID 8858156. S2CID 10194253.
5. Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes". J. Biol. Chem. 275 (24): 18180–7. doi:10.1074/jbc.275.24.18180. PMID 10849440.
6. "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa".
7. Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.

Further reading

• Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity". Mol. Cell. 29 (1): 81–91. doi:10.1016/j.molcel.2007.11.003. PMC 2486835. PMID 18206971.
• Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem. 96 (4): 751–9. doi:10.1002/jcb.20577. PMID 16088961. S2CID 23658728.
• Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes". Mol. Cell. Biol. 25 (1): 206–19. doi:10.1128/MCB.25.1.206-219.2005. PMC 538770. PMID 15601843.
• Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105". J. Biol. Chem. 276 (48): 44963–9. doi:10.1074/jbc.M106112200. PMID 11567023.
• Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription". J. Biol. Chem. 275 (22): 16459–65. doi:10.1074/jbc.275.22.16459. PMID 10828057.
• Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB". EMBO J. 17 (17): 5161–9. doi:10.1093/emboj/17.17.5161. PMC 1170844. PMID 9724652.