TAFA5

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene.[5][6]

TAFA5
Identifiers
Aliases	TAFA5, QLLK5208, TAFA-5, UNQ5208, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, family with sequence similarity 19 member A5, C-C motif chemokine like, TAFA chemokine like family member 5, FAM19A5
External IDs	OMIM: 617499 MGI: 2146182 HomoloGene: 22888 GeneCards: TAFA5
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.32 Start 48,489,460 bp[1] End 48,850,912 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 87,544,299 bp[2] End 87,759,364 bp[2]
Gene ontology Molecular function • cytokine activity Cellular component • membrane • integral component of membrane • extracellular region • extracellular Biological process • regulation of receptor activity • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25817	106014
Ensembl	ENSG00000219438	ENSMUSG00000054863
UniProt	Q7Z5A7	Q91WE9
RefSeq (mRNA)	NM_015381 NM_001082967	NM_001252310 NM_134096
RefSeq (protein)	NP_001076436 NP_056196	NP_001239239 NP_598857
Location (UCSC)	Chr 22: 48.49 – 48.85 Mb	Chr 15: 87.54 – 87.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000219438 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054863 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
6. "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 11 August 2019.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.