TAOK2

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.[5][6][7]

TAOK2
Identifiers
Aliases	TAOK2, MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2, TAO kinase 2
External IDs	OMIM: 613199 MGI: 1915919 HomoloGene: 74531 GeneCards: TAOK2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 29,973,868 bp[1] End 29,992,261 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 126,865,678 bp[2] End 126,884,703 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • mitogen-activated protein kinase kinase binding • ATP binding • MAP kinase kinase kinase activity • neuropilin binding • tau protein binding • tau-protein kinase activity Cellular component • integral component of membrane • cell projection • membrane • receptor complex • dendrite • nucleolus • cytoskeleton • cytoplasmic vesicle membrane • cell nucleus • cytoplasm • cytosol • cytoplasmic vesicle • actin cytoskeleton • axon • neuron projection • dendritic growth cone • axonal growth cone Biological process • phosphorylation • activation of MAPKK activity • protein targeting to membrane • response to stress • positive regulation of JNK cascade • G2 DNA damage checkpoint • cellular response to DNA damage stimulus • protein phosphorylation • focal adhesion assembly • stress-activated MAPK cascade • regulation of cell growth • regulation of cell shape • cell migration • actin cytoskeleton organization • positive regulation of stress-activated MAPK cascade • apoptotic process • regulation of mitotic cell cycle • nervous system development • regulation of apoptotic process • activation of MAPK activity • mitotic G2 DNA damage checkpoint • axonogenesis • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • positive regulation of protein autophosphorylation • activation of protein kinase activity • regulation of actin cytoskeleton organization • autophosphorylation • basal dendrite morphogenesis • basal dendrite arborization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9344	381921
Ensembl	ENSG00000149930	ENSMUSG00000059981
UniProt	Q9UL54	Q6ZQ29
RefSeq (mRNA)	NM_001252043 NM_004783 NM_016151	NM_001163774 NM_001163775
RefSeq (protein)	NP_001238972 NP_004774 NP_057235	NP_001157246 NP_001157247
Location (UCSC)	Chr 16: 29.97 – 29.99 Mb	Chr 7: 126.87 – 126.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TAOK2 has been shown to interact with MAP2K6[8] and MAP2K3.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000149930 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059981 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
6. Hutchison M, Berman KS, Cobb MH (October 1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". The Journal of Biological Chemistry. 273 (44): 28625–32. doi:10.1074/jbc.273.44.28625. PMID 9786855.
7. "Entrez Gene: TAOK2 TAO kinase 2".
8. Chen Z, Cobb MH (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The Journal of Biological Chemistry. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.

Further reading

• Chen Z, Hutchison M, Cobb MH (October 1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". The Journal of Biological Chemistry. 274 (40): 28803–7. doi:10.1074/jbc.274.40.28803. PMID 10497253.
• Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD (February 2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization". The Journal of Biological Chemistry. 275 (6): 4311–22. doi:10.1074/jbc.275.6.4311. PMID 10660600.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD (May 2003). "The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability". The Journal of Biological Chemistry. 278 (20): 18085–91. doi:10.1074/jbc.M213064200. PMID 12639963.
• Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH (June 2003). "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors". The Journal of Biological Chemistry. 278 (25): 22278–83. doi:10.1074/jbc.M301173200. PMID 12665513.
• Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ (September 2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
• Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J (September 2006). "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways". The Journal of Biological Chemistry. 281 (39): 28802–10. doi:10.1074/jbc.M603627200. PMC 1797068. PMID 16893890.
• Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD (March 2007). "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing". The Journal of Biological Chemistry. 282 (9): 6484–93. doi:10.1074/jbc.M608336200. PMID 17158878.
• Wojtala R, Tavares IA, Morton PE, Valderrama F, Thomas NSB, Morris JDH. (2011). "PSKs/TAOKs are activated in mitosis and contribute to mitotic cell rounding and spindle positioning". J. Biol. Chem. 286 (34): 30161–70. doi:10.1074/jbc.M111.228320. PMC 3191055. PMID 21705329.CS1 maint: uses authors parameter (link)
• de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH (June 2012). "Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex". Nature Neuroscience. 15 (7): 1022–31. doi:10.1038/nn.3141. PMC 4017029. PMID 22683681.CS1 maint: uses authors parameter (link)
• Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP and Morris JDH. (2013). "PSKs/TAOKs phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer's disease". J. Biol. Chem. 288 (21): 15418–29. doi:10.1074/jbc.M112.448183. PMC 3663559. PMID 23585562.CS1 maint: uses authors parameter (link)
• Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, Linardopoulos S, Tutt AN, Morris JDH. (2017). "Targeting TAO kinases using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells". Molecular Cancer Therapeutics. 16 (11): 2410–21. doi:10.1158/1535-7163.MCT-17-0077. PMID 28830982.CS1 maint: uses authors parameter (link)
• Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RK, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-Opatz IL, Morellini F, Scherer SW, Singh KK, Calderon de Anda F (February 2018). "Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling". Molecular Psychiatry. 24 (9): 1329–1350. doi:10.1038/s41380-018-0025-5. PMC 6756231. PMID 29467497.
• Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JD (May 2018). "A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies". Acta Neuropathologica Communications. 6 (1): 37. doi:10.1186/s40478-018-0539-8. PMC 5937037. PMID 29730992.