TBCB

Tubulin-folding cofactor B is a protein that in humans is encoded by the TBCB gene.[5][6]

TBCB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V6E, 1WHG
Identifiers
Aliases	TBCB, CG22, CKAP1, CKAPI, tubulin folding cofactor B
External IDs	OMIM: 601303 MGI: 1913661 HomoloGene: 981 GeneCards: TBCB
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 36,114,289 bp[1] End 36,125,947 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,224,131 bp[2] End 30,232,272 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • microtubule cytoskeleton • microtubules • cytoskeleton • cytosol Biological process • multicellular organism development • cell differentiation • nervous system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1155	66411
Ensembl	ENSG00000105254	ENSMUSG00000006095
UniProt	Q99426	Q9D1E6
RefSeq (mRNA)	NM_001300971 NM_001281	NM_025548 NM_001360648 NM_001360649
RefSeq (protein)	NP_001272 NP_001287900	NP_079824 NP_001347577 NP_001347578
Location (UCSC)	Chr 19: 36.11 – 36.13 Mb	Chr 7: 30.22 – 30.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000105254 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006095 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe TK, Shimizu F, Nagata M, Kawai A, Fujiwara T, Nakamura Y, Takahashi E, Hirai Y (Jan 1997). "Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-GLY domain". Cytogenet Cell Genet. 72 (2–3): 208–11. doi:10.1159/000134191. PMID 8978778.
6. "Entrez Gene: TBCB tubulin folding cofactor B".

Further reading

• Wolz W, Wendelmuth U, Rouquier S, et al. (1997). "A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1)". Cytogenet. Cell Genet. 72 (2–3): 215–6. doi:10.1159/000134193. PMID 8978780.
• Tian G, Lewis SA, Feierbach B, et al. (1997). "Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors". J. Cell Biol. 138 (4): 821–32. doi:10.1083/jcb.138.4.821. PMC 2138046. PMID 9265649.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Vadlamudi RK, Barnes CJ, Rayala S, et al. (2005). "p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B". Mol. Cell. Biol. 25 (9): 3726–36. doi:10.1128/MCB.25.9.3726-3736.2005. PMC 1084301. PMID 15831477.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Wang W, Ding J, Allen E, et al. (2006). "Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway". Curr. Biol. 15 (22): 2050–5. doi:10.1016/j.cub.2005.10.052. PMID 16303566.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.