TBL3

Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.[4][5]

TBL3
Identifiers
Aliases	TBL3, SAZD, UTP13, transducin beta like 3
External IDs	OMIM: 605915 MGI: 2384863 HomoloGene: 4711 GeneCards: TBL3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,972,053 bp[1] End 1,982,929 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • snoRNA binding • RNA binding Cellular component • Pwp2p-containing subcomplex of 90S preribosome • small-subunit processome • nucleolus • cell nucleus • nucleoplasm Biological process • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10607	213773
Ensembl	ENSG00000183751	ENSMUSG00000040688
UniProt	Q12788	Q8C4J7
RefSeq (mRNA)	NM_006453	NM_145396
RefSeq (protein)	NP_006444	NP_663371
Location (UCSC)	Chr 16: 1.97 – 1.98 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000183751 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.
5. "Entrez Gene: TBL3 transducin (beta)-like 3".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.