TCP11

T-complex protein 11 homolog is a protein that in humans is encoded by the TCP11 gene.[5][6][7]

TCP11
Identifiers
Aliases	TCP11, D6S230E, FPPR, t-complex 11
External IDs	OMIM: 186982 MGI: 98544 HomoloGene: 8433 GeneCards: TCP11
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.31 Start 35,118,071 bp[1] End 35,148,610 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 14.62 cM Start 28,066,745 bp[2] End 28,080,639 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • Acrosome • cytoplasmic vesicle • sperm flagellum • cell projection • sperm midpiece • motile cilium • cilium Biological process • cell differentiation • spermatogenesis • multicellular organism development • protein kinase A signaling • regulation of cAMP-mediated signaling • regulation of sperm capacitation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6954	21463
Ensembl	ENSG00000124678	ENSMUSG00000062859
UniProt	Q8WWU5	Q01755
RefSeq (mRNA)	NM_001093728 NM_001261817 NM_001261818 NM_001261819 NM_001261820 NM_001261821 NM_018679	NM_001085555 NM_013687 NM_001357681 NM_001374620 NM_001374621
RefSeq (protein)	NP_001248746 NP_001248747 NP_001248748 NP_001248749 NP_001248750 NP_061149 NP_001353252 NP_001353253 NP_001353254 NP_001353255 NP_001353256 NP_001353257 NP_001353258 NP_001353259 NP_001353260 NP_001353261 NP_001357616	n/a
Location (UCSC)	Chr 6: 35.12 – 35.15 Mb	Chr 17: 28.07 – 28.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Model organisms

Model organisms have been used in the study of TCP11 function. A conditional knockout mouse line called Tcp11^{tm1a(EUCOMM)Wtsi} was generated at the Wellcome Trust Sanger Institute.[8] Male and female animals underwent a standardized phenotypic screen[9] to determine the effects of deletion.[10][11][12][13] Additional screens performed: - In-depth immunological phenotyping[14]

Tcp11 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[9][14]
Peripheral blood leukocytes 6 Weeks	Normal
Haematology 6 Weeks	Normal
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

References

1. GRCh38: Ensembl release 89: ENSG00000124678 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062859 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ragoussis J, Senger G, Mockridge I, Sanseau P, Ruddy S, Dudley K, Sheer D, Trowsdale J (Nov 1992). "A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11". Genomics. 14 (3): 673–9. doi:10.1016/S0888-7543(05)80167-3. PMID 1427894.
6. Ma Y, Zhang S, Xia Q, Zhang G, Huang X, Huang M, Xiao C, Pan A, Sun Y, Lebo R, Milunsky A (Jan 2002). "Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide". Molecular Human Reproduction. 8 (1): 24–31. doi:10.1093/molehr/8.1.24. PMID 11756566.
7. "Entrez Gene: TCP11 t-complex 11 (mouse)".
8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
9. "International Mouse Phenotyping Consortium".
10. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
11. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
12. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
13. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
14. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

• Ma YX, Zhang SZ, Wu QQ, Sun Y, Qiu WM, Xu WM (Apr 2003). "[Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 25 (2): 122–8. PMID 12905703.
• Ma YX, Zhang SZ, Wu QQ, Sun Y (Feb 2003). "[Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 35 (2): 182–8. PMID 12545228.
• Fraser LR, Hosseini R, Hanyalogou A, Talmor A, Dudley RK (Nov 1997). "TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction". Molecular Reproduction and Development. 48 (3): 375–82. doi:10.1002/(SICI)1098-2795(199711)48:3<375::AID-MRD11>3.0.CO;2-V. PMID 9322250.
• Mazarakis ND, Nelki D, Lyon MF, Ruddy S, Evans EP, Freemont P, Dudley K (Feb 1991). "Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex". Development. 111 (2): 561–71. PMID 1893875.