TDRKH

Tudor and KH domain-containing protein is a protein that in humans is encoded by the TDRKH gene.[5][6]

TDRKH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIQ, 3FDR, 5J39
Identifiers
Aliases	TDRKH, TDRD2, tudor and KH domain containing
External IDs	OMIM: 609501 MGI: 1919884 HomoloGene: 4999 GeneCards: TDRKH
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,770,107 bp[1] End 151,791,416 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 94,413,273 bp[2] End 94,434,668 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding • nucleic acid binding Cellular component • cytoplasm • pi-body • mitochondrion • piP-body Biological process • male meiotic nuclear division • fertilization • cell differentiation • DNA methylation involved in gamete generation • spermatogenesis • gene silencing by RNA • piRNA metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11022	72634
Ensembl	ENSG00000182134	ENSMUSG00000041912
UniProt	Q9Y2W6	Q80VL1
RefSeq (mRNA)	NM_001083963 NM_001083964 NM_001083965 NM_006862	NM_028307 NM_001357711 NM_001357712 NM_001357713 NM_001357714
RefSeq (protein)	NP_001077432 NP_001077433 NP_001077434 NP_006853	NP_082583 NP_001344640 NP_001344641 NP_001344642 NP_001344643
Location (UCSC)	Chr 1: 151.77 – 151.79 Mb	Chr 3: 94.41 – 94.43 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000182134 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041912 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lamb FS, Barna TJ, Goud C, Marenholz I, Mischke D, Schutte BC (May 2000). "Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains". Gene. 246 (1–2): 209–18. doi:10.1016/S0378-1119(00)00087-1. PMID 10767542.
6. "Entrez Gene: TDRKH tudor and KH domain containing".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Côté J, Richard S (2005). "Tudor domains bind symmetrical dimethylated arginines". J. Biol. Chem. 280 (31): 28476–83. doi:10.1074/jbc.M414328200. PMID 15955813.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.