TEGT

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene.[5][6][7]

TMBIM6
Identifiers
Aliases	TMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
External IDs	OMIM: 600748 MGI: 99682 HomoloGene: 2419 GeneCards: TMBIM6
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 49,707,725 bp[1] End 49,764,934 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 56.13 cM Start 99,392,882 bp[2] End 99,410,049 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • endoribonuclease inhibitor activity • GO:0001948 protein binding • enzyme binding • ubiquitin protein ligase binding Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • mitochondrial membranes • integral component of plasma membrane • endoplasmic reticulum • cell nucleus Biological process • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of endoribonuclease activity • negative regulation of apoptotic signaling pathway • negative regulation of apoptotic process • negative regulation of protein binding • endoplasmic reticulum calcium ion homeostasis • negative regulation of immunoglobulin secretion • response to endoplasmic reticulum stress • autophagy • response to unfolded protein • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • response to L-glutamate • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway • apoptotic process • negative regulation of calcium ion transport into cytosol • negative regulation of RNA splicing • cellular response to unfolded protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7009	110213
Ensembl	ENSG00000139644	ENSMUSG00000023010
UniProt	P55061	Q9D2C7
RefSeq (mRNA)	NM_001098576 NM_003217	NM_001171034 NM_001171035 NM_001171036 NM_026669
RefSeq (protein)	NP_001092046 NP_003208	NP_001164505 NP_001164506 NP_001164507 NP_080945
Location (UCSC)	Chr 12: 49.71 – 49.76 Mb	Chr 15: 99.39 – 99.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000139644 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023010 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.
6. Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.
7. "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID 10087504.
• Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics. 57 (2): 201–8. doi:10.1006/geno.1999.5761. PMID 10198159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC 1868227. PMID 12875974.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer. 106 (3): 648–53. doi:10.1002/cncr.21639. PMID 16353209. S2CID 1629852.
• Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi:10.1074/jbc.M700053200. PMID 17526500.