TELO2

Telomere length regulation protein TEL2 homolog is a protein that in humans is encoded by the TELO2 gene.[5][6][7][8]

TELO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PSI
Identifiers
Aliases	TELO2, CLK2, TEL2, telomere maintenance 2, YHFS
External IDs	OMIM: 611140 MGI: 1918968 HomoloGene: 41107 GeneCards: TELO2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,493,344 bp[1] End 1,510,457 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 25,099,570 bp[2] End 25,115,967 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0032947 molecular adaptor activity • Hsp90 protein binding • GO:0001948 protein binding • protein kinase binding • GO:0032403 macromolecular complex binding • telomeric DNA binding Cellular component • cytoplasm • chromosome, telomeric region • TORC1 complex • TORC2 complex • intracellular • membrane • nuclear periphery • cell nucleus • chromosome • cytosol • nuclear body • nuclear chromosome, telomeric region • ASTRA complex Biological process • positive regulation of TORC1 signaling • protein stabilization • regulation of TOR signaling • positive regulation of TORC2 signaling • positive regulation of protein serine/threonine kinase activity • telomere maintenance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9894	71718
Ensembl	ENSG00000100726	ENSMUSG00000024170
UniProt	Q9Y4R8	Q9DC40
RefSeq (mRNA)	NM_016111 NM_001351846	NM_001163661 NM_027880
RefSeq (protein)	NP_057195 NP_001338775	NP_001157133 NP_082156
Location (UCSC)	Chr 16: 1.49 – 1.51 Mb	Chr 17: 25.1 – 25.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

In 2007, researchers reported an unexpected role for Tel2 in the expression of all mammalian phosphatidylinositol 3-kinase-related protein kinases (PIKKs). Although Tel2 was identified as a budding yeast gene required for the telomere length maintenance, they found no obvious telomeric function for mammalian Tel2. Tel2 deletion also curbed mTOR signaling, indicating that Tel2 affects mammalian PIKKs. Tel2 binds to part of the HEAT repeat segments of ATM and mTOR, and is a highly conserved regulator of PIKK stability.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000100726 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024170 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. Jiang N, Benard CY, Kebir H, Shoubridge EA, Hekimi S (Jun 2003). "Human CLK2 links cell cycle progression, apoptosis, and telomere length regulation". J Biol Chem. 278 (24): 21678–84. doi:10.1074/jbc.M300286200. PMID 12670948.
8. "Entrez Gene: TELO2 TEL2, telomere maintenance 2, homolog (S. cerevisiae)".
9. Takai H, Wang R, Takai K, Yang H, De Lange T (2007). "Tel2 Regulates the Stability of PI3K-Related Protein Kinases". Cell. 131 (7): 1248–1259. doi:10.1016/j.cell.2007.10.052. PMID 18160036. S2CID 6297247.

Further reading

• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y4R8 (Human Telomere length regulation protein TEL2 homolog) at the PDBe-KB.