TFDP2

Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene.[5][6][7]

TFDP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CF7
Identifiers
Aliases	TFDP2, DP2, transcription factor Dp-2
External IDs	OMIM: 602160 MGI: 107167 HomoloGene: 4578 GeneCards: TFDP2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 141,944,428 bp[1] End 142,149,544 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 96,196,275 bp[2] End 96,323,646 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • transcription factor binding • GO:0001948 protein binding • GO:0001104 transcription coregulator activity • protein domain specific binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • transcription regulator complex • nucleoplasm • mitochondrion • RNA polymerase II transcription factor complex Biological process • regulation of transcription from RNA polymerase II promoter • cell cycle • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • GO:0007067 mitotic cell cycle • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • heart development • transcription, DNA-templated • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • negative regulation of G0 to G1 transition • regulation of cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7029	211586
Ensembl	ENSG00000114126	ENSMUSG00000032411
UniProt	Q14188	Q64163
RefSeq (mRNA)	NM_001178138 NM_001178139 NM_001178140 NM_001178141 NM_001178142 NM_006286 NM_001375756 NM_001375773 NM_001375774 NM_001375775 NM_001375776 NM_001375778 NM_001375779 NM_001375780	NM_001184706 NM_001184708 NM_001184709 NM_001184710 NM_001184711 NM_178667
RefSeq (protein)	NP_001171609 NP_001171610 NP_001171611 NP_001171612 NP_001171613 NP_006277 NP_001362685 NP_001362702 NP_001362703 NP_001362704 NP_001362705 NP_001362707 NP_001362708 NP_001362709	n/a
Location (UCSC)	Chr 3: 141.94 – 142.15 Mb	Chr 9: 96.2 – 96.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000114126 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032411 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang Y, Chellappan SP (Jul 1995). "Cloning and characterization of human DP2, a novel dimerization partner of E2F". Oncogene. 10 (11): 2085–93. PMID 7784053.
6. Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics. 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
7. "Entrez Gene: TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)".

Further reading

• Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. doi:10.1128/mcb.15.5.2536. PMC 230484. PMID 7739537.
• Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520.
• Loiseau L, Pasteau S, Brun G (1998). "Molecular cloning and expression pattern of the DP members of the chicken E2F transcription factor". Gene Expr. 6 (5): 259–73. PMC 6148286. PMID 9368098.
• Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179.
• Gaubatz S, Wood JG, Livingston DM (1998). "Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9190–5. doi:10.1073/pnas.95.16.9190. PMC 21314. PMID 9689056.
• Zheng N, Fraenkel E, Pabo CO, Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F–DP". Genes Dev. 13 (6): 666–74. doi:10.1101/gad.13.6.666. PMC 316551. PMID 10090723.
• Korz C, Pscherer A, Benner A, et al. (2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Park KK, Deok Ahn J, Lee IK, et al. (2003). "Inhibitory effects of novel E2F decoy oligodeoxynucleotides on mesangial cell proliferation by coexpression of E2F/DP". Biochem. Biophys. Res. Commun. 308 (4): 689–97. doi:10.1016/S0006-291X(03)01455-4. PMID 12927774.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Overview of all the structural information available in the PDB for UniProt: Q14188 (Transcription factor Dp-2) at the PDBe-KB.