TFEC

Transcription factor EC is a protein that in humans is encoded by the TFEC gene.[5][6]

TFEC
Identifiers
Aliases	TFEC, TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L, transcription factor EC
External IDs	OMIM: 604732 MGI: 1333760 HomoloGene: 32148 GeneCards: TFEC
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.2 Start 115,935,148 bp[1] End 116,159,896 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A2 Start 16,833,373 bp[2] End 16,898,441 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001105 transcription coactivator activity • GO:0001948 protein binding • protein dimerization activity • GO:0001106 transcription corepressor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm Biological process • cellular response to heat • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of nucleic acid-templated transcription • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22797	21426
Ensembl	ENSG00000105967	ENSMUSG00000029553
UniProt	O14948	Q9WTW4
RefSeq (mRNA)	NM_001018058 NM_001244583 NM_012252	NM_031198
RefSeq (protein)	NP_001018068 NP_001231512 NP_036384	NP_112475
Location (UCSC)	Chr 7: 115.94 – 116.16 Mb	Chr 6: 16.83 – 16.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000105967 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029553 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yasumoto K, Shibahara S (Aug 1997). "Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator". Biochim Biophys Acta. 1353 (1): 23–31. doi:10.1016/s0167-4781(97)00034-1. PMID 9256061.
6. "Entrez Gene: TFEC transcription factor EC".

Further reading

• Zhao GQ, Zhao Q, Zhou X, et al. (1993). "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation". Mol. Cell. Biol. 13 (8): 4505–12. doi:10.1128/mcb.13.8.4505. PMC 360062. PMID 8336698.
• Steingrímsson E, Tessarollo L, Reid SW, et al. (1999). "The bHLH-Zip transcription factor Tfeb is essential for placental vascularization". Development. 125 (23): 4607–16. PMID 9806910.
• Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97. doi:10.1021/bi002847d. PMID 11467950.
• Mansky KC, Sulzbacher S, Purdom G, et al. (2002). "The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter". J. Leukoc. Biol. 71 (2): 304–10. PMID 11818452.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.