TFPT

TCF3 fusion partner is a protein that in humans is encoded by the TFPT gene.[5][6][7]

TFPT
Identifiers
Aliases	TFPT, FB1, INO80F, amida, TCF3 (E2A) fusion partner (in childhood Leukemia), TCF3 fusion partner
External IDs	OMIM: 609519 MGI: 1916964 HomoloGene: 8349 GeneCards: TFPT
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,107,013 bp[1] End 54,115,675 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 3,620,324 bp[2] End 3,629,929 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding Cellular component • cytoplasm • not the membrane • Ino80 complex • cell nucleus • nucleoplasm Biological process • apoptotic signaling pathway • apoptotic process • DNA recombination • regulation of transcription, DNA-templated • DNA repair • transcription, DNA-templated • cellular response to DNA damage stimulus • protein deubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29844	69714
Ensembl	ENSG00000275086 ENSG00000276504 ENSG00000274073 ENSG00000276022 ENSG00000276263 ENSG00000278161 ENSG00000105619 ENSG00000276296 ENSG00000276323 ENSG00000273833	ENSMUSG00000006335
UniProt	P0C1Z6	Q3U1J1
RefSeq (mRNA)	NM_013342 NM_001321792	NM_001290381 NM_023524
RefSeq (protein)	NP_001308721 NP_037474 NP_001308721.1	NP_001277310 NP_076013
Location (UCSC)	Chr 19: 54.11 – 54.12 Mb	Chr 7: 3.62 – 3.63 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000276504, ENSG00000274073, ENSG00000276022, ENSG00000276263, ENSG00000278161, ENSG00000105619, ENSG00000276296, ENSG00000276323, ENSG00000273833 GRCh38: Ensembl release 89: ENSG00000275086, ENSG00000276504, ENSG00000274073, ENSG00000276022, ENSG00000276263, ENSG00000278161, ENSG00000105619, ENSG00000276296, ENSG00000276323, ENSG00000273833 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006335 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Irie Y, Yamagata K, Gan Y, Miyamoto K, Do E, Kuo CH, Taira E, Miki N (Feb 2000). "Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells". J Biol Chem. 275 (4): 2647–2653. doi:10.1074/jbc.275.4.2647. PMID 10644725.
6. Jin J, Cai Y, Yao T, Gottschalk AJ, Florens L, Swanson SK, Gutierrez JL, Coleman MK, Workman JL, Mushegian A, Washburn MP, Conaway RC, Conaway JW (Dec 2005). "A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex". J Biol Chem. 280 (50): 41207–41212. doi:10.1074/jbc.M509128200. PMID 16230350.
7. "Entrez Gene: TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)".

Further reading

• Jiang F, Ai J, Xiao W, Wang Z (2007). "FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity". Cancer Lett. 253 (2): 265–272. doi:10.1016/j.canlet.2007.02.003. PMC 1989770. PMID 17395368.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Franchini C, Fontana F, Minuzzo M, et al. (2007). "Apoptosis promoted by up-regulation of TFPT (TCF3 fusion partner) appears p53 independent, cell type restricted and cell density influenced". Apoptosis. 11 (12): 2217–2224. doi:10.1007/s10495-006-0195-5. PMID 17041757. S2CID 37448238.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brambillasca F, Mosna G, Colombo M, et al. (1999). "Identification of a novel molecular partner of the E2A gene in childhood leukemia". Leukemia. 13 (3): 369–375. doi:10.1038/sj/leu/2401338. PMID 10086727.