TGM4

Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene.[5][6][7]

TGM4
Identifiers
Aliases	TGM4, TGP, hTGP, TGASE–4, transglutaminase 4
External IDs	OMIM: 600585 MGI: 3027002 HomoloGene: 20689 GeneCards: TGM4
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 44,874,608 bp[1] End 44,914,990 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F4 Start 123,034,726 bp[2] End 123,067,561 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • transferase activity, transferring acyl groups • protein-glutamine gamma-glutamyltransferase activity • metal ion binding Cellular component • cytoplasm • extracellular matrix • Golgi apparatus • extracellular exosome • collagen-containing extracellular matrix Biological process • peptide cross-linking Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7047	331046
Ensembl	ENSG00000163810 ENSG00000281886	ENSMUSG00000025787
UniProt	P49221	Q8BZH1
RefSeq (mRNA)	NM_003241	NM_177911
RefSeq (protein)	NP_003232	NP_808579
Location (UCSC)	Chr 3: 44.87 – 44.91 Mb	Chr 9: 123.03 – 123.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000281886 GRCh38: Ensembl release 89: ENSG00000163810, ENSG00000281886 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025787 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gentile V, Grant FJ, Porta R, Baldini A (Oct 1995). "Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization". Genomics. 27 (1): 219–20. doi:10.1006/geno.1995.1032. PMID 7665178.
6. Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ (Oct 1994). "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library". Biochem Biophys Res Commun. 203 (2): 1117–23. doi:10.1006/bbrc.1994.2298. PMID 7916568.
7. "Entrez Gene: TGM4 transglutaminase 4 (prostate)".

Further reading

• Davies G, Ablin RJ, Mason MD, Jiang WG (2007). "Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer". J. Exp. Ther. Oncol. 6 (3): 257–64. PMID 17552366.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dubbink HJ, de Waal L, van Haperen R, et al. (1998). "The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization". Genomics. 51 (3): 434–44. doi:10.1006/geno.1998.5393. PMID 9721214.
• Dubbink HJ, Verkaik NS, Faber PW, et al. (1996). "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase". Biochem. J. 315 ( Pt 3) (Pt 3): 901–8. doi:10.1042/bj3150901. PMC 1217292. PMID 8645175.
• Amendola A, Lombardi G, Oliverio S, et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A". FEBS Lett. 339 (3): 258–64. doi:10.1016/0014-5793(94)80427-3. PMID 7906657. S2CID 39872629.
• Mariniello L, Esposito C, Di Pierro P, et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro". Eur. J. Biochem. 215 (1): 99–104. doi:10.1111/j.1432-1033.1993.tb18011.x. PMID 7688299.