THAP7

THAP domain-containing protein 7 is a protein that in humans is encoded by the THAP7 gene.[5][6]

THAP7
Identifiers
Aliases	THAP7, THAP domain containing 7
External IDs	OMIM: 609518 MGI: 1916259 HomoloGene: 12293 GeneCards: THAP7
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 20,999,104 bp[1] End 21,002,196 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 Start 17,527,982 bp[2] End 17,531,136 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • C2H2 zinc finger domain binding • GO:0001948 protein binding • metal ion binding • protein N-terminus binding • nucleic acid binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear speck • chromosome • cell nucleus • not the membrane • intracellular membrane-bounded organelle Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80764	69009
Ensembl	ENSG00000184436	ENSMUSG00000022760
UniProt	Q9BT49	Q8VCZ3
RefSeq (mRNA)	NM_030573 NM_001008695 NM_001008696	NM_026909
RefSeq (protein)	NP_001008695 NP_085050	NP_081185
Location (UCSC)	Chr 22: 21 – 21 Mb	Chr 16: 17.53 – 17.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000184436 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022760 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP (Feb 2003). "The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase". Trends Biochem Sci. 28 (2): 66–9. doi:10.1016/S0968-0004(02)00013-0. PMID 12575992.
6. "Entrez Gene: THAP7 THAP domain containing 7".

Further reading

• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Macfarlan T, Parker JB, Nagata K, Chakravarti D (2006). "Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription". Mol. Endocrinol. 20 (2): 335–47. doi:10.1210/me.2005-0248. PMID 16195249.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Macfarlan T, Kutney S, Altman B, et al. (2005). "Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor". J. Biol. Chem. 280 (8): 7346–58. doi:10.1074/jbc.M411675200. PMID 15561719.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.