THG1L

Probable tRNA(His) guanylyltransferase is an enzyme that in humans is encoded by the THG1L gene.[5][6]

THG1L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OTB, 3OTC, 3OTD, 3OTE
Identifiers
Aliases	THG1L, ICF45, IHG-1, hTHG1, tRNA-histidine guanylyltransferase 1 like, SCAR28, IHG1, THG1
External IDs	MGI: 1913878 HomoloGene: 5959 GeneCards: THG1L
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 157,731,420 bp[1] End 157,741,449 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.1 Start 45,946,843 bp[2] End 45,955,494 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • tRNA binding • GTP binding • GO:0001948 protein binding • ATP binding • magnesium ion binding • metal ion binding • tRNA guanylyltransferase activity • identical protein binding • nucleotidyltransferase activity Cellular component • cytoplasm • cytosol • mitochondrion Biological process • tRNA modification • protein homotetramerization • tRNA processing • tRNA 5'-end processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54974	66628
Ensembl	ENSG00000113272	ENSMUSG00000011254
UniProt	Q9NWX6	Q9CY52
RefSeq (mRNA)	NM_017872 NM_001317824 NM_001317825 NM_001317826	NM_001080969 NM_001290737
RefSeq (protein)	NP_001304753 NP_001304754 NP_001304755 NP_060342	NP_001074438 NP_001277666
Location (UCSC)	Chr 5: 157.73 – 157.74 Mb	Chr 11: 45.95 – 45.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000113272 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000011254 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. "Entrez Gene: THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Guo D, Hu K, Lei Y, et al. (2005). "Identification and characterization of a novel cytoplasm protein ICF45 that is involved in cell cycle regulation". J. Biol. Chem. 279 (51): 53498–505. doi:10.1074/jbc.M406737200. PMID 15459185.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.