THOC2

THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene.[5][6]

THOC2
Identifiers
Aliases	THOC2, CXorf3, THO2, dJ506G2.1, hTREX120, MRX12, MRX35, THO complex 2
External IDs	OMIM: 300395 MGI: 2442413 HomoloGene: 69669 GeneCards: THOC2
Gene location (Human) Chr. X chromosome (human)[1] Band Xq25 Start 123,600,561 bp[1] End 123,733,056 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A4 Start 41,794,991 bp[2] End 41,920,674 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding • mRNA binding Cellular component • THO complex • nuclear speck • THO complex part of transcription export complex • transcription export complex • nuclear chromosome, telomeric region • cell nucleus • nucleoplasm Biological process • poly(A)+ mRNA export from nucleus • mRNA processing • mRNA transport • neuron development • viral mRNA export from host cell nucleus • RNA splicing • generation of neurons • RNA export from nucleus • mRNA export from nucleus • mRNA 3'-end processing • cell morphogenesis • blastocyst development • regulation of gene expression • regulation of mRNA export from nucleus • negative regulation of neuron projection development • stem cell division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57187	331401
Ensembl	ENSG00000125676	ENSMUSG00000037475
UniProt	Q8NI27	B1AZI6
RefSeq (mRNA)	NM_001081550 NM_020449	NM_001033422
RefSeq (protein)	NP_001075019	NP_001028594
Location (UCSC)	Chr X: 123.6 – 123.73 Mb	Chr X: 41.79 – 41.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

THO2 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000125676 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037475 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. doi:10.1038/nature746. PMID 11979277.
6. "Entrez Gene: THOC2 THO complex 2".

Further reading

• Coffey AJ, Brooksbank RA, Brandau O, et al. (1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene". Nat. Genet. 20 (2): 129–35. doi:10.1038/2424. PMID 9771704.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.