THYN1

Thymocyte nuclear protein 1 is a protein that in humans is encoded by the THYN1 gene.[5][6][7]

THYN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EOP, 5J3E
Identifiers
Aliases	THYN1, MDS012, MY105, THY28, THY28KD, HSPC144, thymocyte nuclear protein 1
External IDs	OMIM: 613739 MGI: 1925112 HomoloGene: 8575 GeneCards: THYN1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q25 Start 134,248,279 bp[1] End 134,253,370 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 26,999,710 bp[2] End 27,007,336 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29087	77862
Ensembl	ENSG00000151500	ENSMUSG00000035443
UniProt	Q9P016	Q91YJ3
RefSeq (mRNA)	NM_001037304 NM_001037305 NM_014174 NM_199297 NM_199298	NM_144543 NM_001326361
RefSeq (protein)	NP_001032381 NP_001032382 NP_054893 NP_954994 NP_954995	NP_001313290 NP_653126
Location (UCSC)	Chr 11: 134.25 – 134.25 Mb	Chr 9: 27 – 27.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000151500 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035443 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jiang XZ, Toyota H, Yoshimoto T, Takada E, Asakura H, Mizuguchi J (Nov 2003). "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells". Apoptosis. 8 (5): 509–19. doi:10.1023/A:1025594409056. PMID 14601557. S2CID 2092518.
6. Miyaji H, Yoshimoto T, Asakura H, Komachi A, Kamiya S, Takasaki M, Mizuguchi J (Oct 2002). "Molecular cloning and characterization of the mouse thymocyte protein gene". Gene. 297 (1–2): 189–96. doi:10.1016/S0378-1119(02)00886-7. PMID 12384300.
7. "Entrez Gene: THYN1 thymocyte nuclear protein 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiang X, Toyota H, Takada E, et al. (2004). "Modulation of mThy28 nuclear protein expression during thymocyte development". Tissue & Cell. 35 (6): 471–8. doi:10.1016/S0040-8166(03)00073-9. PMID 14580360.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Song AX, Chang YG, Gao YG, et al. (2005). "Identification, expression, and purification of a unique stable domain from human HSPC144 protein". Protein Expr. Purif. 42 (1): 146–52. doi:10.1016/j.pep.2005.03.008. PMID 15939300.