TIAF1

TGFB1-induced anti-apoptotic factor 1 is a protein that in humans is encoded by the TIAF1 gene.[3][4]

TIAF1
Identifiers
Aliases	TIAF1, MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1
External IDs	OMIM: 609517 HomoloGene: 130531 GeneCards: TIAF1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 29,073,521 bp[1] End 29,078,857 bp[1]
Gene ontology Molecular function • molecular function Cellular component • cell nucleus Biological process • I-kappaB kinase/NF-kappaB signaling • negative regulation of apoptotic process • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9220	n/a
Ensembl	ENSG00000221995	n/a
UniProt	O95411	n/a
RefSeq (mRNA)	NM_004740	n/a
RefSeq (protein)	NP_004731	n/a
Location (UCSC)	Chr 17: 29.07 – 29.08 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interactions

TIAF1 has been shown to interact with Janus kinase 3[5] and TRIB3.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000221995 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Chang NS, Mattison J, Cao H, Pratt N, Zhao Y, Lee C (December 1998). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity". Biochemical and Biophysical Research Communications. 253 (3): 743–9. doi:10.1006/bbrc.1998.9846. PMID 9918798.
4. "Entrez Gene: TIAF1 TGFB1-induced anti-apoptotic factor 1".
5. Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochemical and Biophysical Research Communications. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
6. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cellular Signalling. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading

• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival". Biochemical and Biophysical Research Communications. 270 (1): 267–71. doi:10.1006/bbrc.2000.2413. PMID 10733938.
• Mori K, Furusawa T, Okubo T, Inoue T, Ikawa S, Yanai N, Mori KJ, Obinata M (April 2003). "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)". Journal of Biochemistry. 133 (4): 405–13. doi:10.1093/jb/mvg053. PMID 12761286.
• van der Leij J, van den Berg A, Albrecht EW, Blokzijl T, Roozendaal R, Gouw AS, de Jong KP, Stegeman CA, van Goor H, Chang NS, Poppema S (June 2003). "High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells". Transplantation. 75 (12): 2076–82. doi:10.1097/01.TP.0000069829.71088.88. PMID 12829915. S2CID 24178625.
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (March 2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". The Journal of Biological Chemistry. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Schultz L, Khera S, Sleve D, Heath J, Chang NS (January 2004). "TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53". DNA and Cell Biology. 23 (1): 67–74. doi:10.1089/104454904322745943. PMID 14965474.
• Homma K, Kikuno RF, Nagase T, Ohara O, Nishikawa K (November 2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". Journal of Molecular Biology. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
• Isogawa Y, Kon T, Inoue T, Ohkura R, Yamakawa H, Ohara O, Sutoh K (April 2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site". Biochemistry. 44 (16): 6190–6. doi:10.1021/bi0475931. PMID 15835906.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.