TICAM2

TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.[4]

TICAM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M1W
Identifiers
Aliases	TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2
External IDs	OMIM: 608321 MGI: 3040056 HomoloGene: 11014 GeneCards: TICAM2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.3 Start 115,578,650 bp[1] End 115,602,479 bp[1]
Gene ontology Molecular function • signal transducer activity • GO:0001948 protein binding Cellular component • cytoplasm • endosome • late endosome • Golgi apparatus • early endosome membrane • membrane • late endosome membrane • cell membrane • early endosome • endoplasmic reticulum • endosome membrane • secretory granule membrane Biological process • toll-like receptor 4 signaling pathway • negative regulation of chemokine (C-C motif) ligand 5 production • immune system process • TRAM-dependent toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • inflammatory response • cellular response to lipopolysaccharide • I-kappaB kinase/NF-kappaB signaling • negative regulation of toll-like receptor 4 signaling pathway • MyD88-independent toll-like receptor signaling pathway • signal transduction • GO:0060554, GO:0060555 necroptosis • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway • innate immune system • neutrophil degranulation • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of interleukin-18-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353376	225471
Ensembl	ENSG00000243414	ENSMUSG00000056130
UniProt	Q86XR7	Q8BJQ4
RefSeq (mRNA)	NM_021649	NM_173394
RefSeq (protein)	NP_067681 NP_001157940 NP_001157941	NP_775570
Location (UCSC)	Chr 5: 115.58 – 115.6 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM][4]

References

1. GRCh38: Ensembl release 89: ENSG00000243414 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: TICAM2 toll-like receptor adaptor molecule 2".

Further reading

• Sullivan C, Postlethwait JH, Lage CR, et al. (2007). "Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates". J. Immunol. 178 (7): 4517–27. doi:10.4049/jimmunol.178.7.4517. PMID 17372010.
• Rowe DC, McGettrick AF, Latz E, et al. (2006). "The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction". Proc. Natl. Acad. Sci. U.S.A. 103 (16): 6299–304. doi:10.1073/pnas.0510041103. PMC 1458872. PMID 16603631.
• Yamamoto M, Sato S, Hemmi H, et al. (2003). "TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway". Nat. Immunol. 4 (11): 1144–50. doi:10.1038/ni986. PMID 14556004. S2CID 13016860.
• Oshiumi H, Sasai M, Shida K, et al. (2004). "TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta". J. Biol. Chem. 278 (50): 49751–62. doi:10.1074/jbc.M305820200. PMID 14519765.
• Fitzgerald KA, Rowe DC, Barnes BJ, et al. (2003). "LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF". J. Exp. Med. 198 (7): 1043–55. doi:10.1084/jem.20031023. PMC 2194210. PMID 14517278.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Bin LH, Xu LG, Shu HB (2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". J. Biol. Chem. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

External links

• Overview of all the structural information available in the PDB for UniProt: Q86XR7 (TIR domain-containing adapter molecule 2) at the PDBe-KB.