TIMM9

Mitochondrial import inner membrane translocase subunit Tim9 is an enzyme that in humans is encoded by the TIMM9 gene.[5][6][7]

TIMM9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BSK
Identifiers
Aliases	TIMM9, TIM9, TIM9A, translocase of inner mitochondrial membrane 9
External IDs	OMIM: 607384 MGI: 1353436 HomoloGene: 40847 GeneCards: TIMM9
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 58,408,495 bp[1] End 58,427,531 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 C2|12 Start 71,123,173 bp[2] End 71,136,684 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • chaperone binding • GO:0001948 protein binding • protein homodimerization activity • metal ion binding • transporter activity Cellular component • mitochondrial inner membrane • mitochondrial intermembrane space • mitochondrial intermembrane space protein transporter complex • membrane • mitochondrion • TIM22 mitochondrial import inner membrane insertion complex Biological process • protein transport • protein import into mitochondrial inner membrane • protein targeting to mitochondrion • chaperone-mediated protein transport • sensory perception of sound Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26520	30056
Ensembl	ENSG00000100575	ENSMUSG00000021079
UniProt	Q9Y5J7	Q9WV98
RefSeq (mRNA)	NM_001304485 NM_001304486 NM_001304487 NM_001304488 NM_001304489 NM_001304490 NM_001304491 NM_012460	NM_001024853 NM_001024854 NM_001286203 NM_013896
RefSeq (protein)	NP_001291414 NP_001291415 NP_001291416 NP_001291417 NP_001291418 NP_001291419 NP_001291420 NP_036592	NP_001020024 NP_001020025 NP_001273132 NP_038924
Location (UCSC)	Chr 14: 58.41 – 58.43 Mb	Chr 12: 71.12 – 71.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space.

These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000100575 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021079 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
6. Muhlenbein N, Hofmann S, Rothbauer U, Bauer MF (Mar 2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J Biol Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
7. "Entrez Gene: TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)".

Further reading

• Webb CT, Gorman MA, Lazarou M, et al. (2006). "Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller". Mol. Cell. 21 (1): 123–33. doi:10.1016/j.molcel.2005.11.010. PMID 16387659.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vial S, Lu H, Allen S, et al. (2002). "Assembly of Tim9 and Tim10 into a functional chaperone". J. Biol. Chem. 277 (39): 36100–8. doi:10.1074/jbc.M202310200. PMID 12138093.
• Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". J. Biol. Chem. 276 (40): 37327–34. doi:10.1074/jbc.M105313200. PMID 11489896.
• Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480.