TINAG

Tubulointerstitial nephritis antigen is a protein that in humans is encoded by the TINAG gene.[5][6]

TINAG
Identifiers
Aliases	TINAG, TIN-AG, tubulointerstitial nephritis antigen
External IDs	OMIM: 606749 MGI: 1349477 HomoloGene: 8082 GeneCards: TINAG
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 54,307,859 bp[1] End 54,390,142 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 D Start 76,951,693 bp[2] End 77,045,794 bp[2]
Gene ontology Molecular function • scavenger receptor activity • nucleotide binding • cysteine-type endopeptidase activity • polysaccharide binding • cysteine-type peptidase activity Cellular component • basement membrane • extracellular region • lysosome • extracellular Biological process • cell adhesion • proteolysis involved in cellular protein catabolic process • receptor-mediated endocytosis • immune response • proteolysis • vesicle-mediated transport • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27283	26944
Ensembl	ENSG00000137251	ENSMUSG00000032357
UniProt	Q9UJW2	n/a
RefSeq (mRNA)	NM_014464	NM_012033
RefSeq (protein)	NP_055279	n/a
Location (UCSC)	Chr 6: 54.31 – 54.39 Mb	Chr 9: 76.95 – 77.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000137251 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ikeda M, Takemura T, Hino S, Yoshioka K (Mar 2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen". Biochem Biophys Res Commun. 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID 10652240.
6. "Entrez Gene: TINAG tubulointerstitial nephritis antigen".

Further reading

• Katz A, Fish AJ, Santamaria P, et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy". Am. J. Med. 93 (6): 691–8. doi:10.1016/0002-9343(92)90205-P. PMID 1466368.
• Butkowski RJ, Kleppel MM, Katz A, et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms". Kidney Int. 40 (5): 838–46. doi:10.1038/ki.1991.283. PMID 1762287.
• Fliger FD, Wieslander J, Brentjens JR, et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis". Kidney Int. 31 (3): 800–7. doi:10.1038/ki.1987.69. PMID 3553704.
• Chen Y, Krishnamurti U, Wayner EA, et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen". Kidney Int. 49 (1): 153–7. doi:10.1038/ki.1996.20. PMID 8770961.
• Nelson TR, Kim Y, Michael AF, et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron". Connect. Tissue Res. 37 (1–2): 53–60. doi:10.3109/03008209809028899. PMID 9643646.
• Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMC 4940194. PMID 10581025.
• Zhou B, Nelson TR, Kashtan C, et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag)". J. Am. Soc. Nephrol. 11 (4): 658–68. PMID 10752525.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.