TINAGL1

Tubulointerstitial nephritis antigen-like is a protein that in humans is encoded by the TINAGL1 gene.[5][6]

TINAGL1
Identifiers
Aliases	TINAGL1, ARG1, LCN7, LIECG3, TINAGRP, tubulointerstitial nephritis antigen like 1
External IDs	OMIM: 616064 MGI: 2137617 HomoloGene: 41472 GeneCards: TINAGL1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 31,576,485 bp[1] End 31,587,686 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 130,164,454 bp[2] End 130,175,122 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • scavenger receptor activity • polysaccharide binding • cysteine-type endopeptidase activity • laminin binding • extracellular matrix structural constituent • GO:0001948 protein binding • cysteine-type peptidase activity Cellular component • cytoplasm • extracellular matrix • extracellular region • lysosome • extracellular exosome • extracellular • collagen-containing extracellular matrix Biological process • endosomal transport • cell adhesion • proteolysis involved in cellular protein catabolic process • receptor-mediated endocytosis • immune response • proteolysis • endocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64129	94242
Ensembl	ENSG00000142910	ENSMUSG00000028776
UniProt	Q9GZM7	Q99JR5
RefSeq (mRNA)	NM_001204414 NM_001204415 NM_022164	NM_001168333 NM_023476
RefSeq (protein)	NP_001191343 NP_001191344 NP_071447	NP_001161805 NP_075965
Location (UCSC)	Chr 1: 31.58 – 31.59 Mb	Chr 4: 130.16 – 130.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000142910 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028776 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wex T, Lipyansky A, Bromme NC, Wex H, Guan XQ, Bromme D (Feb 2001). "TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells". Biochemistry. 40 (5): 1350–7. doi:10.1021/bi002266o. PMID 11170462.
6. "Entrez Gene: TINAGL1 tubulointerstitial nephritis antigen-like 1".

Further reading

• Brömme NC, Wex T, Wex H, et al. (2000). "Cloning, characterization, and expression of the human TIN-ag-RP gene encoding a novel putative extracellular matrix protein". Biochem. Biophys. Res. Commun. 271 (2): 474–80. doi:10.1006/bbrc.2000.2639. PMID 10799322.
• Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Umeyama H, Iwadate M, Taguchi YH (2014). "TINAGL1 and B3GALNT1 are potential therapy target genes to suppress metastasis in non-small cell lung cancer". BMC Genomics. 15 (Suppl 9): S2. doi:10.1186/1471-2164-15-S9-S2. PMC 4290609. PMID 25521548.
• Bosse K, Haneder S, Arlt C, Ihling CH, Seufferlein T, Sinz A (2016). "Mass spectrometry-based secretome analysis of non-small cell lung cancer cell lines". Proteomics. 16 (21): 2801–2814. doi:10.1002/pmic.201600297. PMID 27569058. S2CID 38155519.