TIPIN

TIMELESS-interacting protein is a protein that in humans is encoded by the TIPIN gene.[5][6][7]

TIPIN
Identifiers
Aliases	TIPIN, TIMELESS interacting protein
External IDs	OMIM: 610716 MGI: 1921571 HomoloGene: 32373 GeneCards: TIPIN
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 66,336,191 bp[1] End 66,386,746 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 C|9 34.6 cM Start 64,281,581 bp[2] End 64,305,424 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • DNA binding Cellular component • intracellular membrane-bounded organelle • nuclear chromatin • cell nucleus • nucleoplasm • cytoplasm • replication fork protection complex Biological process • cell cycle phase transition • intra-S DNA damage checkpoint • cellular response to DNA damage stimulus • cell division • DNA replication checkpoint • regulation of nuclear cell cycle DNA replication • positive regulation of cell proliferation • cell cycle • replication fork arrest • replication fork protection • DNA damage checkpoint • response to UV • DNA replication Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54962	66131
Ensembl	ENSG00000075131	ENSMUSG00000032397
UniProt	Q9BVW5	Q91WA1
RefSeq (mRNA)	NM_001289986 NM_017858	NM_025372 NM_001324556 NM_001324557 NM_001324558
RefSeq (protein)	NP_001276915 NP_060328	NP_001311485 NP_001311486 NP_001311487 NP_079648
Location (UCSC)	Chr 15: 66.34 – 66.39 Mb	Chr 9: 64.28 – 64.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TIPIN has been shown to interact with Replication protein A1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000075131 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032397 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gotter AL (Aug 2003). "Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association". Journal of Molecular Biology. 331 (1): 167–76. doi:10.1016/S0022-2836(03)00633-8. PMID 12875843.
6. Yoshizawa-Sugata N, Masai H (Jan 2007). "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint". The Journal of Biological Chemistry. 282 (4): 2729–40. doi:10.1074/jbc.M605596200. PMID 17102137.
7. "Entrez Gene: TIPIN TIMELESS interacting protein".
8. Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.

Further reading

• Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (Apr 2007). "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement". Molecular and Cellular Biology. 27 (8): 3131–42. doi:10.1128/MCB.02190-06. PMC 1899931. PMID 17296725.
• Gotter AL, Suppa C, Emanuel BS (Feb 2007). "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors". Journal of Molecular Biology. 366 (1): 36–52. doi:10.1016/j.jmb.2006.10.097. PMC 4151250. PMID 17141802.
• Chou DM, Elledge SJ (Nov 2006). "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18143–7. doi:10.1073/pnas.0609251103. PMC 1654129. PMID 17116885.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.