TJP3

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.[5]

TJP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KFV
Identifiers
Aliases	TJP3, ZO-3, ZO3, tight junction protein 3
External IDs	OMIM: 612689 MGI: 1351650 HomoloGene: 8458 GeneCards: TJP3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 3,708,362 bp[1] End 3,750,813 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,273,207 bp[2] End 81,291,581 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27134	27375
Ensembl	ENSG00000105289	ENSMUSG00000034917
UniProt	O95049	Q9QXY1
RefSeq (mRNA)	NM_014428 NM_001267560 NM_001267561	NM_001282095 NM_001282096 NM_013769
RefSeq (protein)	NP_001254489 NP_001254490	n/a
Location (UCSC)	Chr 19: 3.71 – 3.75 Mb	Chr 10: 81.27 – 81.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TJP3 has been shown to interact with tight junction protein 1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105289 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034917 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TJP3 tight junction protein 3 (zona occludens 3)".
6. Wittchen ES, Haskins J, Stevenson BR (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological Chemistry. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.

Further reading

• Roh MH, Liu CJ, Laurinec S, Margolis B (July 2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". The Journal of Biological Chemistry. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
• Kausalya PJ, Reichert M, Hunziker W (September 2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells". FEBS Letters. 505 (1): 92–6. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048. S2CID 13489358.
• Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (December 1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". The Journal of Cell Biology. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
• Wittchen ES, Haskins J, Stevenson BR (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological Chemistry. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
• Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR (April 1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin". The Journal of Cell Biology. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.