TLE4

Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.[5][6]

TLE4
Identifiers
Aliases	TLE4, BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4, transducin like enhancer of split 4, TLE family member 4, transcriptional corepressor, E(spl)
External IDs	OMIM: 605132 MGI: 104633 HomoloGene: 38259 GeneCards: TLE4
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.31 Start 79,571,773 bp[1] End 79,726,882 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 9.11 cM Start 14,448,150 bp[2] End 14,598,051 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin binding • GO:0001948 protein binding • repressing transcription factor binding • GO:0001106 transcription corepressor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • molecular function Cellular component • cell nucleus • nucleoplasm • transcription regulator complex • beta-catenin-TCF complex Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway • transcription, DNA-templated • beta-catenin-TCF complex assembly • cellular response to leukemia inhibitory factor • biological process • negative regulation of canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7091	21888
Ensembl	ENSG00000106829	ENSMUSG00000024642
UniProt	Q04727	Q62441
RefSeq (mRNA)	NM_001282748 NM_001282749 NM_001282753 NM_001282760 NM_007005 NM_001351541 NM_001351542 NM_001351543 NM_001351546 NM_001351547 NM_001351550 NM_001351552 NM_001351558 NM_001351560 NM_001351562 NM_001351563 NM_001351564 NM_001351556	NM_011600 NM_001302947 NM_001302950 NM_001302951
RefSeq (protein)	NP_001269677 NP_001269678 NP_001269682 NP_001269689 NP_008936 NP_001338470 NP_001338471 NP_001338472 NP_001338475 NP_001338476 NP_001338479 NP_001338481 NP_001338487 NP_001338489 NP_001338491 NP_001338492 NP_001338493 NP_001338485	NP_001289876 NP_001289879 NP_001289880 NP_035730
Location (UCSC)	Chr 9: 79.57 – 79.73 Mb	Chr 19: 14.45 – 14.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TLE4 has been shown to interact with PAX5.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000106829 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024642 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyasaka H, Choudhury BK, Hou EW, Li SS (August 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
6. "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".
7. Eberhard D, Jiménez G, Heavey B, Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". The EMBO Journal. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.
8. Milili M, Gauthier L, Veran J, Mattei MG, Schiff C (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology. 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.

Further reading

• Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (October 1992). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". Nature Genetics. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260. S2CID 32142845.
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Eberhard D, Jiménez G, Heavey B, Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". The EMBO Journal. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.
• Milili M, Gauthier L, Veran J, Mattei MG, Schiff C (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology. 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Heimbucher T, Murko C, Bajoghli B, Aghaallaei N, Huber A, Stebegg R, Eberhard D, Fink M, Simeone A, Czerny T (January 2007). "Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors". Molecular and Cellular Biology. 27 (1): 340–51. doi:10.1128/MCB.00811-06. PMC 1800652. PMID 17060451.