TMED1

Transmembrane emp24 domain-containing protein 1 is a protein that in humans is encoded by the TMED1 gene.[4][5][6]

TMED1
Identifiers
Aliases	TMED1, IL1RL1LG, Il1rl1l, Tp24, p24g1, transmembrane p24 trafficking protein 1
External IDs	OMIM: 605395 MGI: 106201 HomoloGene: 21360 GeneCards: TMED1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,832,067 bp[1] End 10,836,318 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • GO:0001948 protein binding Cellular component • integral component of membrane • Golgi apparatus • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum-Golgi intermediate compartment • cell membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • COPII-coated ER to Golgi transport vesicle Biological process • protein transport • signal transduction • cell-cell signaling • intracellular protein transport • ER to Golgi vesicle-mediated transport • Golgi organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11018	17083
Ensembl	ENSG00000099203	ENSMUSG00000032180
UniProt	Q13445	Q3V009
RefSeq (mRNA)	NM_006858	NM_010744 NM_001324510
RefSeq (protein)	NP_006849	NP_001311439 NP_034874
Location (UCSC)	Chr 19: 10.83 – 10.84 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1). This protein lacks any similarity to other interleukin 1 ligands. The functional significance of its interaction with IL1RL1 is not known.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.
5. Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.
6. "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.