TMED2

Transmembrane emp24 domain-containing protein 2 is a protein that in humans is encoded by the TMED2 gene.[4][5]

TMED2
Identifiers
Aliases	TMED2, P24A, RNP24, p24, p24b1, p24beta1, transmembrane p24 trafficking protein 2
External IDs	MGI: 3704329 HomoloGene: 55991 GeneCards: TMED2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 123,584,533 bp[1] End 123,598,582 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • transport vesicle • integral component of membrane • ER to Golgi transport vesicle membrane • Golgi apparatus • Golgi membrane • intracellular membrane-bounded organelle • Golgi cisterna membrane • zymogen granule membrane • membrane • endoplasmic reticulum • endoplasmic reticulum membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • COPI-coated vesicle • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum-Golgi intermediate compartment • COPI-coated vesicle membrane • COPII-coated ER to Golgi transport vesicle Biological process • cargo loading into vesicle • neural tube closure • maternal placenta development • embryonic placenta development • COPII vesicle coating • ER to Golgi vesicle-mediated transport • heart looping • positive regulation of gene expression • somitogenesis • Golgi organization • post-anal tail morphogenesis • embryonic morphogenesis • multicellular organism growth • in utero embryonic development • protein transport • GO:0034259 negative regulation of GTPase activity • COPI coating of Golgi vesicle • labyrinthine layer blood vessel development • vesicle-mediated transport • somite rostral/caudal axis specification • intracellular protein transport • retrograde vesicle-mediated transport, Golgi to ER • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10959	100862175
Ensembl	ENSG00000086598	n/a
UniProt	Q15363	Q9R0Q3
RefSeq (mRNA)	NM_006815 NM_001321445	XM_003945446
RefSeq (protein)	NP_001308374 NP_006806	NP_062744
Location (UCSC)	Chr 12: 123.58 – 123.6 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TMED2 has been shown to interact with GORASP1[6] and GORASP2.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000086598 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Blum R, Feick P, Puype M, Vandekerckhove J, Klengel R, Nastainczyk W, Schulz I (July 1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking". The Journal of Biological Chemistry. 271 (29): 17183–9. doi:10.1074/jbc.271.29.17183. PMID 8663407.
5. "Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2".
6. Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

Further reading

• Fiedler K, Veit M, Stamnes MA, Rothman JE (September 1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors". Science. 273 (5280): 1396–9. Bibcode:1996Sci...273.1396F. doi:10.1126/science.273.5280.1396. PMID 8703076. S2CID 13159384.
• Gommel D, Orci L, Emig EM, Hannah MJ, Ravazzola M, Nickel W, Helms JB, Wieland FT, Sohn K (March 1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway". FEBS Letters. 447 (2–3): 179–85. doi:10.1016/S0014-5793(99)00246-X. PMID 10214941. S2CID 41832392.
• Majoul I, Straub M, Hell SW, Duden R, Söling HD (July 2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET". Developmental Cell. 1 (1): 139–53. doi:10.1016/S1534-5807(01)00004-1. PMID 11703931.
• Barr FA, Preisinger C, Kopajtich R, Körner R (December 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". The Journal of Cell Biology. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P (April 2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature. 440 (7088): 1208–12. Bibcode:2006Natur.440.1208C. doi:10.1038/nature04667. PMID 16641999. S2CID 4349251.
• Luo W, Wang Y, Reiser G (October 2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking". The Journal of Biological Chemistry. 282 (41): 30246–55. doi:10.1074/jbc.M703205200. PMID 17693410.