TNFAIP1

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene.[5][6][7]

TNFAIP1
Identifiers
Aliases	TNFAIP1, B12, B61, BTBD34, EDP1, hBACURD2, TNF alpha induced protein 1
External IDs	OMIM: 191161 MGI: 104961 HomoloGene: 22519 GeneCards: TNFAIP1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,335,602 bp[1] End 28,347,009 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,522,850 bp[2] End 78,536,332 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ubiquitin-protein transferase activity • GTP-Rho binding • GO:0001948 protein binding • protein domain specific binding • identical protein binding Cellular component • cytoplasm • endosome • Cul3-RING ubiquitin ligase complex • nucleolus • cell nucleus Biological process • positive regulation of DNA replication • DNA replication • negative regulation of Rho protein signal transduction • protein homooligomerization • cell migration • protein ubiquitination • immune response • stress fiber assembly • proteasome-mediated ubiquitin-dependent protein catabolic process • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7126	21927
Ensembl	ENSG00000109079	ENSMUSG00000017615
UniProt	Q13829	O70479
RefSeq (mRNA)	NM_021137	NM_001159392 NM_009395
RefSeq (protein)	NP_066960	NP_001152864 NP_033421
Location (UCSC)	Chr 17: 28.34 – 28.35 Mb	Chr 11: 78.52 – 78.54 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000109079 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017615 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O'Rourke K, Ward PA, Prochownik EV, Marks RM (Mar 1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J Biol Chem. 265 (5): 2973–8. PMID 2406243.
6. Holzman LB, Marks RM, Dixit VM (Dec 1990). "A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein". Mol Cell Biol. 10 (11): 5830–8. doi:10.1128/MCB.10.11.5830. PMC 361366. PMID 2233719.
7. "Entrez Gene: TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)".

Further reading

• Wolf FW, Marks RM, Sarma V, et al. (1992). "Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene". J. Biol. Chem. 267 (2): 1317–26. PMID 1370465.
• Pandey A, Shao H, Marks RM, et al. (1995). "Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis". Science. 268 (5210): 567–9. doi:10.1126/science.7536959. PMID 7536959.
• Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Link CD, Taft A, Kapulkin V, et al. (2003). "Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model". Neurobiol. Aging. 24 (3): 397–413. doi:10.1016/S0197-4580(02)00224-5. PMID 12600716. S2CID 22679483.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.