TNPO2

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.[5][6][7]

TNPO2
Identifiers
Aliases	TNPO2, IPO3, KPNB2B, TRN2, transportin 2
External IDs	OMIM: 603002 MGI: 2384849 HomoloGene: 8381 GeneCards: TNPO2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,699,194 bp[1] End 12,724,011 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 85,036,915 bp[2] End 85,057,583 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nuclear localization sequence binding • Ran GTPase binding Cellular component • not the membrane • nuclear periphery • cell nucleus • cytoplasm Biological process • protein transport • intracellular protein transport • ribosomal protein import into nucleus • NLS-bearing protein import into nucleus • protein import into nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	30000	212999
Ensembl	ENSG00000105576	ENSMUSG00000031691
UniProt	O14787	Q99LG2
RefSeq (mRNA)	NM_013433 NM_001136195 NM_001136196	NM_001122843 NM_145390 NM_001364031 NM_001364032 NM_001364033 NM_001364034 NM_001379096
RefSeq (protein)	NP_001129667 NP_001129668 NP_038461 NP_001369165 NP_001369166 NP_001369167 NP_001369168 NP_001369169 NP_001369170 NP_001369171 NP_001369172 NP_001129667.1 NP_038461.2	NP_001116315 NP_663365 NP_001350960 NP_001350961 NP_001350962 NP_001350963 NP_001366025
Location (UCSC)	Chr 19: 12.7 – 12.72 Mb	Chr 8: 85.04 – 85.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TNPO2 has been shown to interact with NXF1,[6] NUP98[8] and Ran (biology).[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105576 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031691 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (September 1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". The Journal of Cell Biology. 138 (6): 1181–92. doi:10.1083/jcb.138.6.1181. PMC 2132560. PMID 9298975.
6. Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14195–9. Bibcode:2002PNAS...9914195S. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
7. "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)".
8. Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". The Journal of Biological Chemistry. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.

Further reading

• Gallouzi IE, Steitz JA (November 2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309. S2CID 43726887.
• Blanc V, Kennedy S, Davidson NO (October 2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling". The Journal of Biological Chemistry. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
• Güttinger S, Mühlhäusser P, Koller-Eichhorn R, Brennecke J, Kutay U (March 2004). "Transportin2 functions as importin and mediates nuclear import of HuR". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2918–23. Bibcode:2004PNAS..101.2918G. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
• Rebane A, Aab A, Steitz JA (April 2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR". RNA. 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
• Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang Z, Chook YM (August 2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.