TOE1

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene.[5][6]

TOE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FC6
Identifiers
Aliases	TOE1, hCaf1z, target of EGR1, member 1 (nuclear), PCH7, target of EGR1, exonuclease
External IDs	OMIM: 613931 MGI: 1915526 HomoloGene: 11823 GeneCards: TOE1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 45,340,052 bp[1] End 45,343,973 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 116,794,310 bp[2] End 116,807,640 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • GO:0001948 protein binding • metal ion binding • nucleic acid binding • poly(A)-specific ribonuclease activity • snRNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cytoplasm • Cajal body • nuclear speck • nucleolus • nucleoplasm • cell nucleus • nuclear body Biological process • RNA phosphodiester bond hydrolysis, exonucleolytic • snRNA 3'-end processing • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114034	68276
Ensembl	ENSG00000132773	ENSMUSG00000028688
UniProt	Q96GM8	Q9D2E2
RefSeq (mRNA)	NM_025077	NM_026654
RefSeq (protein)	NP_079353	NP_080930
Location (UCSC)	Chr 1: 45.34 – 45.34 Mb	Chr 4: 116.79 – 116.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000132773 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028688 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
6. "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.